摘要
试验以小花棘豆为研究对象,测定其总黄酮提取物在体内的抗氧化活性。采用超声波协助提取法提取小花棘豆中总黄酮,并使用肝脏损伤小鼠模型(四氯化碳造模)测定小花棘豆总黄酮提取物在体内的抗氧化活性。结果表明,小花棘豆总黄酮可以显著提高小鼠血清和肝脏中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性,并降低丙二醛(MDA)含量和脑组织中脂褐素(LP)含量。因此,小花棘豆总黄酮具有一定的体内抗氧化活性,有一定的利用前景。
The purpose of this project was to study the anti-oxidant activity in vivo of total flavonoids from Oxytropis gla- bra DC. Ultrasonic-assisted extraction was adopted to extract total flavonoids from Oxytropis glabra DC. Mice model of car- bon tetrachloride （CC14） liver injury was used to assay the antioxidant ability in vivo of total flavonoids. In mice serum and liv- er, total flavnoids from Oxytropis glabra DC could markedly increase the activity of superoxide dismutase （SOD） and glutathi- one peroxidase （GSH-Px）, and decrease the content of maleic dialdehyde （MDA） and lipofuscim（LP）. Therefore, total fla- vnoids from Oxytropis glabra DC had antioxidant activity in vivo to some extant, which provided for its further developing and researching.
出处
《中国畜牧兽医》
CAS
北大核心
2012年第10期133-136,共4页
China Animal Husbandry & Veterinary Medicine
基金
"十二五"国家科技支撑计划(2011BA017B05)
新疆生产建设兵团博士基金专项(2008JC07)
新疆生产建设兵团塔里木畜牧科技重点实验室开放课题(HS201207)
关键词
小花棘豆
总黄酮
体内抗氧化活性
Oxytropis glabra DC
total flavonoids
antioxidant activity in vivo
