摘要
目的通过分析突发性聋(sudden deafness,SD)患者血液中各项易栓症(thrombophlilia)的发生率,进一步明确突聋的发病原因及指导临床诊疗。方法选择我科2009年11月～2010年7月期间诊断明确的突聋患者43例(43耳)为突聋组,另选30例健康体检者为对照组,对所有受试者的遗传性易栓症指标包括抗凝血酶Ⅲ(AT-Ⅲ)活性、蛋白C(PC)活性、蛋白S(PS)活性、血清同型半胱氨酸(Hcy)及获得性易栓症指标D-二聚体(D-D)的阳性率进行分析。结果 43例突聋患者遗传性易栓症的总发生率为46.5%,其中Hcy的阳性率为44.1%,PS阳性率为23.3%;获得性易栓症D-D的阳性率为67.4%,与对照组比较,差异有统计学意义(P<0.05),AT-Ⅲ、PC两组比较差异无统计学意义(P>0.05)。结论突聋患者易栓症发病率高,尤其是获得性易栓症,其血液高凝状态可能是由遗传性和获得性易栓症共同作用的结果。
Objective To analyze the incidence of thrombophlilia in patients with sudden deafness （SD） to help deter-mine the etiology and guide treatment. Methods Forty-three patients （43 ears） with SD as a group and 30 healthy subjects （the control group） were tested. Tests for inherited thrombophilia included anticoagulant Ⅲ （AT-Ⅲ） activity, protein C （PC） activity, protein S （PS） activity, homocysteine （Hcy） and acquired thrombophilia indicator D-dimer （D-D）. Results The overall positive rate for inherited thrombophilia in SD group was 46.5%. In particular, the positive rate was 44.1% with Hcy, 23.3% with PS and 67.4% with D-D. Compared with the control group, the positive rate was either remarkably increased, as in Hcy and D-D, or decreased as in PS （P〈0.05）, although AT-Ⅲ and PC showed no significant difference between the two groups （P〉0.05）. Conclusion The incidence of thrombophilia, especially acquired thrombophilia, is high in SD patients. Both inherited and acquired tbrombophilia may contribute to the hypercoagulability in SD patients.
出处
《中华耳科学杂志》
CSCD
北大核心
2012年第3期345-348,共4页
Chinese Journal of Otology
基金
武警总医院苗圃基金
突发性聋的病因学分析
编号WZ2009010
关键词
突发性聋
易栓症
遗传性
获得性
血栓
Sudden deafness
Thrombophilia
Inherited factors
Acquired factors
