摘要
目的观察单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法 82例HIE患儿随机数表法分为2组,治疗组41例,即在常规治疗基础上加用单唾液酸四己糖神经节苷脂,静脉滴注20 mg/d,1次/d,10～14 d为1疗程;对照组41例,即在常规治疗基础上加用胞二磷胆碱静滴0.125 g/d,1次/d,10～14 d为1疗程。治疗前、治疗1疗程后进行临床体征恢复时间检查。结果治疗组总有效率明显高于对照组,差异有统计学意义(χ2=4.586,P<0.05)。2组患儿在治疗前相关指标无差异。治疗后2组患儿在原始反射、肌张力、意识状态及惊厥的恢复时间之间的差异有统计学意义(t值分别为4.262、3.516、3.271、2.595,P值均小于<0.05)。结论单唾液酸四己糖神经节苷脂治疗组临床体征恢复时间明显优于对照组,临床在新生儿缺氧缺血性脑病综合治疗基础上加用单唾液酸四己糖神经节苷脂,可以提高治疗有效率及改善预后。
Objective To explore the clinical efficacy of using monosialotetrahexosyl ganglioside as concomitant in treating neonatal hypoxic-ischemic encephalopathy（HIE）.Methods 82 HIE neonates were randomized into two groups：41 in a treatment group,who were given conventional therapy plus monosialotetrahexosyl ganglioside（20 mg/d of intravenous drip,once per day,10~14 days as a course of treatment）;41 in a control group,who were given conventional therapy plus cytidine diphosphate choline（0.125 g/d of intravenous drip,once per day,10~14 days as a course of treatment）.Before the treatment and after one course of treatment,the recovery time of clinical symptoms were assessed.Results The total efficacy of the treatment group was significantly better than that of the control group.The difference was of statistic significance.（χ2 =4.586,P0.05）.Compared indicators of the two groups were of no meaningful difference before treatment.After the treatment,the differences between the two groups in terms of primitive reflex,muscle tension,conscious state and the recovery time of convulsion were statistically significant（t=4.262,3.516,3.271,2.595,P0.05）.Conclusion Clinical symptoms as for recovery time of the treatment group are significantly better than those of the control group.The use of monosialotetrahexosyl ganglioside as concomitant in treating neonatal HIE can improve therapeutic efficacy and prognosis.
出处
《淮海医药》
CAS
2012年第6期494-495,496,共3页
Journal of Huaihai Medicine
关键词
缺氧缺血性脑病
单唾液酸四己糖神经节苷脂
治疗结果
Neonatal hypoxic-ischemic encephalopathy
Monosialotetrahexosyl ganglioside
Treatment outcome
