摘要
目的观察老年下肢手术患者围手术期血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、S-100β变化,探讨术后认知功能障碍的(postoperative cognitive dysfunction,POCD)发生与NSE、S-100β变化的关系。方法择期行下肢手术的老年患者86例,分别于术前24h、术后6h以及48h进行老年认知功能量表(the scale of elderly congitive fuction,SECF)测定;同时检测术前24h、术后6h以及48h血清中NSE、S-100β蛋白水平。结果①术后共有21例患者被诊断为POCD。②NSE水平在术后6h以及48h均明显升高,与术前24h相比差异有显著统计学意义;③S-100β仅在术后6h显著升高,与术前24h相比差异有显著统计学意义;术后48h下降至术前水平。④发生POCD的患者,其术后NSE以及S-100β蛋白水平明显高于未发生者。结论老年患者术后NSE、S-100β蛋白水平明显升高,血清中NSE、S-100β蛋白水平的变化与POCD的发生有密切关系。
Objective To observe the changes of serum neuron-neuron specific enolase （NSE） and S-100β in elderly patients undergoing lower limb surgery, analyze their relationship with postoperative cognitive dysfunction （POCD）. Methods 86 cases of elderly patients undergoing lower extremity surgery were selected in this study. The congnitive function was evaluated at 24 hours before and 6, 48 hours after surgery in all 86 patients with the scale of elderly congitive fuction （SECF）. At the same time, the concentration of serum NSE and S-100β were detected 24 h before surgery, 6 h and 48 h after the surgery. Results ① 21 patients were diagnosed with POCD. ②The level of NSE at the time of 6 h and 48 h after surgury increased significantly compared with 24 h before surgery. ③S-100β only significantly increased at 6h after surgery. ④Compared with non-POCD patients, the levels of NSE and S-100β were significantly higher in POCD patients. Conclusions Serum NSE and S-100β protein levels significantly increase after operation, which are closely correlated with POCD in elderly patients.
出处
《临床医学工程》
2012年第10期1699-1700,1702,共3页
Clinical Medicine & Engineering
基金
湖北省襄阳市科技局科研课题(襄科计[2010]10号)
关键词
术后认知功能障碍
老年认知功能量表
NSE
S-100Β
Postoperative cognitive dysfunction （POCD）
Scale of elderly congitive fuction （SECF）
NSE
S-100β
