期刊文献+

长效胰岛素类似物的疗效与安全性——该如何平衡

Evaluation of efficacy and safety of long-acting insulin analogues
下载PDF
导出
摘要 权衡药物的疗效和安全性,在药物诞生之初就一直存在。胰岛素类似物作为一种替代人体自身胰岛素的体外激素,尤其是在患者体内长期起效的长效胰岛素类似物,其安全性自然更加受到关注。对低血糖的影响,对体重的影响,以及胰岛素的长期安全性,都对临床一线医生选择胰岛素产生了一定影响。本文分别对几种临床常用的长效胰岛素的疗效和安全性进行综述,以便临床医生能够更好地了解不同长效胰岛素之间的特点与差异。
作者 母义明
出处 《药品评价》 CAS 2012年第25期42-45,共4页 Drug Evaluation
  • 相关文献

参考文献18

  • 1Miller CD,Phillips LS,Ziemer DC,et al.Hypoglycemia in patients with type 2 diabetes mellitus[J].Arch Intern Med,2001,161(13):1653-1659.
  • 2Goudswaard AN,Furlong NJ,Rutten GE,et al.Insulin monotherapy versus combinations of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitus[J].Cochrane Database Syst Rev,2004,18(4):CD003418.
  • 3Horvath K,Jeitler K,Berghold A,et al.Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus[J].Cochrane Database Syst Rev,2007,18(2):CD005613.
  • 4Heise T,Nosek L,Ronn BB,et al.Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes[J].Diabetes,2004,53:1614-1620.
  • 5Niskanen L,Virkamaki A,Hansen JB,et al.Fasting plasma glucose variability as a marker of nocturnal hypoglycemia in diabetes:evidence from the PREDICTIVE study[J].Diabetes Res ClinPract,2009,86(2):e15-e18.
  • 6Blonde L,Merilainen M,Karwe V,et al.Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue:an assessment of two different fasting plasma glucose targets-the TITRATE study[J].Diabetes ObesMetab,2009,11(6):623-631.
  • 7Yki-Jarvinen H,Ryysy L,Kauppila M,et al.Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus[J].J Clin Endocrinol Metab,1997,82(12):4037-4043.
  • 8The Diabetes control and complications Research Group.Adverse events and their association with treatment regimens in the diabetes control and complications trial[J].Diabetes Care,1995,18:1415-1427.
  • 9UK Prospective Diabetes study(UKPDs)Group.Intensive bloodglucose control with sulphonyIureas or insuIin compared with conventional treatment an risk of complications in patients with type 2 diabetes(UKPDS 33)[J].Lancet,1998,352:837-853.
  • 10Raslova K,Bogoev M,Raz I,et al.Insulin detemir and insulin aspart:a promising basal-bolus regimen for type 2 diabetes[J].Diabetes Res Clin Pract,2004,66(2):193-201.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部