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Toxicity of graphene oxide and multi-walled carbon nanotubes against human cells and zebrafish 被引量:13

Toxicity of graphene oxide and multi-walled carbon nanotubes against human cells and zebrafish
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摘要 Graphene possesses unique physical and chemical properties, which have inspired a wide range of potential biomedical applications. However, little is known about the adverse effects of graphene on the human body and ecological environment. The purpose of our work is to make assessment on the toxicity of graphene oxide (GO) against human cell line (human bone marrow neuroblastoma cell line and human epithelial carcinoma cell line) and zebrafish (Danio rerio) by comparing the toxic effects of GO with its sister, multi-walled carbon nanotubes (MWNTs). The results show that GO has a moderate toxicity to organisms since it can induce minor (about 20%) cell growth inhibition and slight hatching delay of zebrafish embryos at a dosage of 50 mg/L, but did not result in significant increase of apoptosis in embryo, while MWNTs exhibit acute toxicity leading to a strong inhibition of cell proliferation and serious morphological defects in developing embryos even at relatively low concentration of 25 mg/L. The distinctive toxicity of GO and MWNTs should be ascribed to the different models of interaction between nanomaterials and organisms, which arises from the different geometric structures of nanomaterials. Collectively, our work suggests that GO does actual toxicity to organisms posing potential environmental risks and the result is also shedding light on the geometrical structure-dependent toxicity of graphitic nanomaterials. Graphene possesses unique physical and chemical properties, which have inspired a wide range of potential biomedical applications. However, little is known about the adverse effects of graphene on the human body and ecological environment. The purpose of our work is to make assessment on the toxicity of graphene oxide (GO) against human cell line (human bone marrow neuroblastoma cell line and human epithelial carcinoma cell line) and zebrafish (Danio rerio) by comparing the toxic effects of GO with its sister, multi-walled carbon nanotubes (MWNTs). The results show that GO has a moderate toxicity to organisms since it can induce minor (about 20%) cell growth inhibition and slight hatching delay of zebrafish embryos at a dosage of 50 mg/L, but did not result in significant increase of apoptosis in embryo, while MWNTs exhibit acute toxicity leading to a strong inhibition of cell proliferation and serious morphological defects in developing embryos even at relatively low concentration of 25 mg/L. The distinctive toxicity of GO and MWNTs should be ascribed to the different models of interaction between nanomaterials and organisms, which arises from the different geometric structures of nanomaterials. Collectively, our work suggests that GO does actual toxicity to organisms posing potential environmental risks and the result is also shedding light on the geometrical structure-dependent toxicity of graphitic nanomaterials.
出处 《Science China Chemistry》 SCIE EI CAS 2012年第10期2209-2216,共8页 中国科学(化学英文版)
基金 supported by the National Natural Science Foundation of China (21035005) the Doctoral Program Foundation of Institutions of Higher Education of China (20115301120002) the Natural Science Foundation of Yunnan Province of China (2011FB007)
关键词 graphene oxide multi-walled carbon nanotubes TOXICITY cellular apoptosis ZEBRAFISH 多壁碳纳米管 毒性作用 氧化石墨 人体细胞 斑马鱼 生物医学应用 神经母细胞瘤 纳米材料
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  • 1Zerda ADL, Zavaleta C, Keren S, Vaithilingam S, Bodapati S, Liu Z, Levi J, Smith BR, Ma T-J, Oralkan 0, Cheng Z, Chen X, Dai H, Khuri-Yakub BT, Gambhir SS. Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat Biotech, 2008, 3: 557-562.
  • 2Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat Biotech, 2008, 26: 1285-1292.
  • 3Zhang L. Zhen SJ, Sang Y, Li JY, Wang v, Zhan L, Peng L, Wang J, Li YF, Huang CZ. Controllable preparation of metal nanoparticlel carbon nanotube hybrids as efficient dark field light scattering agents for cell imaging. Chern Commun, 2010, 46: 4303-4305.
  • 4Liu Z, Fan AC, Rakhra K, Sherlock S, Goodwin A, Chen XY, Yang QW, Felsher DW, Dai HJ. Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. Angew Chern Int Ed, 2009,48: 7668-7672.
  • 5Zhen SJ, Chen LQ, Xiao SJ, Li YF, Hu PP, Zhan L, Peng L, Song EQ, Huang CZ. Carbon nanotubes as a low background signal platform for a molecular aptamer beacon on the basis of long-range resonance energy transfer. Anal Chern, 2010, 82: 8432-8437.
  • 6Zhao YL, Xing GM, Chai ZF. Nanotoxicology: Are carbon nanotubes safe? Nat Nano, 2008, 3: 191-192.
  • 7Schipper ML, Nakayama-Ratchford N, Davis CR, Kam NWS, Chu P, Liu Z, Sun X, Dai H, Gambhir SS. A pilot toxicology study of singlewalled carbon nanotubes in a small sample of mice. Nat Nano, 2008, 3:216-221.
  • 8Jia G, Wang HF, Yan L, Wang X, Pei RJ, Yan T, Zhao YL, Guo XB. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multiwall nanotube, and fullerene. Environ Sci Technol, 2005, 39: 1378- 1383.
  • 9Geim AK. Graphene: Status and prospects. Science, 2009, 324: 1530-1534.
  • 10Li XL, Wang XR, Zhang L, Lee SW, Dai HJ. Chemically derived, ultrasmooth graphene nanoribbon semiconductors. Science, 2008, 319: 1229-1232.

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