摘要
目的:观察黄连温胆汤加减对老年代谢综合征胰岛素抵抗及血清瘦素水平的影响。方法:选取2010年1月至2011年12月我院收治的老年代谢综合征患者126例,给予黄连温胆汤加减治疗,对比治疗前后患者体重、血压(BP)、空腹血糖(FBG)、血清胰岛素(INS)、血脂以及血清瘦素水平。结果:治疗后FBG,INS以及胰岛素抵抗指数(IRI)均低于治疗前,IRI为(4.36±1.25),明显低于治疗前(8.31±2.18),治疗后患者的血清胆固醇、甘油三酯低于治疗前,高密度脂蛋白胆固醇高于治疗前;治疗后瘦素水平[(6.83±2.31)μg.L-1]明显低于治疗前[(22.65±4.39)μg.L-1],各项指标治疗前后比较差异有统计学意义(P<0.05)。结论:黄连温胆汤加减可控制血糖、改善胰岛素抵抗、降血脂、降低瘦素水平,是治疗代谢综合征的有效方药。
Objective： To observe the influence of Huanglian Wendan decoction plus or minus on insulin resistance and serum leptin levels of elderly metabolic syndrome. Method： One hundred and twentysix cases of elderly patients with metabolic syndrome hospitalized from January, 2010 to december, 2011 were given Huanglian Wendan decoction plus or minus and the comparison was carried out before and after treatment for body weight, blood pressure （BP） , fasting plasma glucose （FBG） , serum insulin （INS） , insulin resistance index （IRI） , lipids, and serum leptin and other indicators. Result： After treatment, FBG, INS, and IRI were lower compared with those before treatment. IRI was （4.36 ± 1.25） , significantly lowered than that before treatment （8.31 ± 2. 18）. After treatment serum concentrations, triglyceride concentration were lower compared with those before treatment. High-density lipoprotein cholesterol （HDL-C） was increased after treatment; leptin level was significantly lowered from （22.65 ±4.39） μg ·L^（-1） before treatment to （6. 83±2.31 ） μg ·L^（-1） after the treatment. The difference was statistically significant （ P 〈 0.05 ）. Conclusion ： Huanglian Wendan decoction plus or minus can control blood sugar, improve insulin resistance, lowering blood pressure, lower level of leptin. It is an effective prescription for the treatment of metabolic syndrome.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第21期313-315,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
老年代谢综合征
黄连温胆汤
胰岛素抵抗
血脂
血清瘦素
elderly metabolic syndrome
Huanglian Wendan decoction
insulin resistance
serum lipids
serum leptin
