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冠心病患者抗血小板治疗的新选择 被引量：5

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摘要 血栓是导致心血管事件的主要原因，在冠心病的发生发展中起着重要作用。多项临床研究表明，抗血小板药物可以改善冠心病患者的预后。尽管如此，在双联抗血小板治疗时心血管缺血事件的再发生率仍高达9．3％～12．1％。此外，抗血小板药物导致部分患者发生出血事件。因此，研发新的抗血小板药物，评估抗栓药物疗效及安全性成为目前冠心病治疗领域的研究热点。
作者 冯雪茹 刘梅林
机构地区 北京大学第一医院老年内科
出处 《中华医学杂志》 CAS CSCD 北大核心 2012年第38期2668-2670,共3页 National Medical Journal of China
关键词 抗血小板治疗 冠心病患者 抗血小板药物 心血管事件 临床研究 缺血事件 出血事件 药物疗效
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

  • 1Jneid H,Anderson JL,Wright RS, et al. 2012 ACCF/AHAFocused Update of the Guideline for the Management of PatientsWith Unstable Angina/Non-ST-Elevation Myocardial Infarction(Updating the 2007 Guideline and Replacing the 2011 FocusedUpdate) : a report of the American College of CardiologyFoundation/American Heart Association Task Force on PracticeGuidelines. Circulation, 2012,126:875-910.
  • 2The Task Force on the management of ST-segment elevation acutemyocardial infarction of the European Society of Cardiology. ESCGuidelines for the management of acute myocardial infarction inpatients presenting with ST-segment elevation. Eur Heart J, 2012,doi:10.1093/eurheartj/ehs215.
  • 3Guyatt GH,Akl EA,Crowther M,et al. Antithrombotic therapyand prevention of thrombosis,9th ed : American College of ChestPhysicians Evidence-Based Clinical Practice Guidelines. Chest,2012,141(2 Suppl) ;7S47S.
  • 4Price MJ, Angiolillo DJ, Teirstein PS, et al. Platelet reactivityand cardiovascular outcomes after percutaneous coronaryintervention : a time-dependent analysis of the GaugingResponsiveness with a Verify Now P2Y12 assay: Impact onThrombosis and Safety ( GRAVITAS) trial. Circulation, 2011,124:1132-1137.
  • 5Trenk D, Stone GW, Gawaz M, et al. A randomized trial ofprasugrel versus clopidogrel in patients with high platelet reactivityon clopidogrel after elective percutaneous coronary interventionwith implantation of drug-eluting stents : results of the TRIGGER-PCI ( Testing Platelet Reactivity In Patients Undergoing ElectiveStent Placement on Clopidogrel to Guide Alternative Therapy WithPrasugrel) study. J Am Coll Cardiol, 2012,59:2159-2164.
  • 6Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. Areport of the American College of Cardiology Foundation/AmericanHeart Association Task Force on Practice Guidelines and theSociety for Cardiovascular Angiography and Interventions. J AmColl Caidiol, 2011,58:e44-el22.
  • 7冯雪茹,刘梅林,刘芳,田清平,范琰,刘倩竹.老年患者阿司匹林反应性及其影响因素分析[J].中华心血管病杂志,2011,39(10):925-928. 被引量：14
  • 8Mega JL, Close SL, Wiviott SD,et al. Cytochrome p-450polymorphisms and response to clopidogrel. N Engl J Med,2009,360:354-362.

二级参考文献12

  • 1张妍,梁静,周玉杰,袁慧,张永志,董磊.服用阿司匹林后血小板聚集功能对介入治疗后心肌坏死指标的影响[J].中华心血管病杂志,2005,33(8):695-699. 被引量：8
  • 2李小鹰.阿司匹林在动脉硬化性心血管疾病中的临床应用:中国专家共识(2005)[J].中华心血管病杂志,2006,34(3):281-284. 被引量：194
  • 3胡大一,孙艺红.正确认识阿司匹林“抵抗”[J].中华心血管病杂志,2006,34(12):1057-1058. 被引量：10
  • 4Krasopoulos G,Brister SJ,Beattie WS,et al.Aspirin “resistance” and risk of cardiovascular morbidity:systematic review and meta-analysis.BMJ,2008,336:195-198.
  • 5Gum PA,Kottke-Marchant K,Welsh PA,et al.A prospective,blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease.J Am Coll Cardiol,2003,41:961-965.
  • 6Gori AM,Marcucci R,Migliorini A,et al.Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents.J Am Coll Cardiol,2008,52:734-739.
  • 7Marcucci R,Gori AM,Paniccia R,et al.Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy.Atherosclerosis,2007,195:e217-e223.
  • 8Ben-Dor I,Kleiman NS,Lev E.Assessment,mechanisms,and clinical implication of variability in platelet response to aspirin and clopidogrel therapy.Am J Cardiol,2009,104:227-233.
  • 9US Preventive Services Task Force.Aspirin for the prevention of cardiovascular disease:U.S.preventive services task force recommendation statement.Ann Intern Med,2009,150:396-404.
  • 10Bhatt DL,Scheiman J,Abraham NS.ACCF/ACG/AHA 2008expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use:a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.J Am Coll Cardiol,2008,52:1502-1517.

共引文献13

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二级引证文献44

中华医学杂志
2012年 第38期

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