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Progress in the study of cancer-associated retinopathy in breast cancer patients

癌症相关性视网膜病变在乳腺癌中的研究进展(英文)
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摘要 Cancer-associated retinopathy (CAR) typically has a sudden or progressive onset of severe visual loss and an ominous association with an occult malignancy which contains breast cancer. Pathologically, CAR is the degeneration of photoreceptors. But the precise mechanism has not been fully established, CAR may result from autoimmune mediated apoptosis. And in recent years, there also have been some results demonstrating that tumor derived angiogenic factors such as VEGF may also confer the development of CAR, which may offer novel avenues for the therapeutic intervention in CAR. Early initiation of immunosuppressive therapy is critical for vision preservation. Future developments in rapid identification and longitudinal quantification of antibody levels would enable individualized management in these patients. The goal of this review was to analyze the epidemiology, the clinical features, the diagnosis and management of retinopathy in the context of recent advances in the elucidation of breast cancer-associated retinopathy (BCAR) pathogenesis.
出处 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第10期566-571,共6页 中德临床肿瘤学杂志(英文版)
关键词 paraneoplastic retinopathy autoimmune retinopathy cancer-associated retinopathy (CAR) RECOVERIN cytotoxicT-lymphocyte immune therapy 糖尿病视网膜病变 乳腺癌 癌症 患者 血管生成因子 发病机制 恶性肿瘤 汽车发展
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参考文献47

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