摘要
目的了解分离自石家庄市6家医院冷却塔水的嗜肺军团菌的药物敏感性。方法采用K-B纸片扩散法对30株分离自冷却塔水的嗜肺军团菌进行8大类26种抗生素的药敏实验,参照WS/T125—1999《中华人民共和国卫生行业标准纸片法抗菌药物敏感试验标准》读取结果。结果 30株嗜肺军团菌均对头孢呋辛、强力霉素、四环素、链霉素、环丙沙星、左旋氧氟沙星、莫西沙星、红霉素、阿奇霉素、克拉霉素、利福平、氧氟沙星共12种抗生素敏感,对头孢唑林、氨曲南、氨苄西林、头孢噻吩、头孢他啶、妥布霉素、头孢西丁共7种抗生素均产生不同程度的耐药。实验菌株共产生了8种耐药谱,菌株存在多重耐药性。结论 30株嗜肺军团菌对青霉素类、头孢菌素类、氨基糖苷类耐药较普遍。对大环内酯类、喹诺酮类、利福平类抗生素体外药敏结果优于其他类抗生素,可作为临床治疗军团菌感染的参考用药。
Objective To study＇the drug sensitivity and resistance of Legionella pneumophila isolated from six hospital cooling towers of Shijizhuang. Methods Eight major categories and 26 kinds of antibiotics drug test on 30 strains of Legionella pneumophila isolated from hospital cooling tower by using K-B disk diffusion method. The drug susceptibility testing results were reported refer to the national Health Industry Standard Paper film method （antimicrobial WS/T125-1999）. Results The sensitivity of 30 strains of Legionella pneumophila to Cefuroxime, doxycycline, tetracycline, streptomycin, ciprofloxacin, levofloxacin, moxifloxacin, erythromycin, azithromycin, clarithromycin, rifampicin and ofloxacin was 100%, and they presented different levels of resistance to cefazolin, aztreonam, ampicillin, cephalothin, ceftazidime, tobramycin and cefoxitin. Experimental strains produced eight kinds of resistance spectrum, they were multi-drug resistant strains. Conclusion Resistance is more common to penicillins, cephalosporins, aminoglycosides among 30 starins of Legionella pneumophila. Macrolides, quinolones, rifampicin is superior to the other kinds of antibiotics in vitro susceptibility test, respectively, and these antibiotics can be used as the first choice in clinical therapy of Legionella infections.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2012年第10期920-922,共3页
Journal of Environment and Health
关键词
嗜肺军团菌
医院
冷却塔
药敏
Legionella pneumophila
Hospital
Cooling tower
Drug sensitivity
