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干细胞标志物CD44在胃肠道肿瘤中研究现状

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摘要 目前认为,胃肠道肿瘤或是一种干细胞疾病,可由干细胞突变而来。肿瘤干细胞不仅启动肿瘤发生,且参与肿瘤细胞侵袭和转移。但肿瘤干细胞参与胃肠道肿瘤发生、侵袭和转移的分子机制尚不清楚。对肿瘤干细胞来说鉴别特异性细胞表面标志物尤为重要。某些特异性标志物或候选基因极可能在胃肠癌干细胞参与肿瘤侵袭、转移机制中起重要作用。近年来,作为胃肠道癌的标志物,CD44的研究进展较为引人注目,本文予以简介。
出处 《腹部外科》 2012年第5期313-315,共3页 Journal of Abdominal Surgery
基金 国家自然科学基金(81101850) 上海市教委基金(12YZ047)
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