摘要
目的分析甲状腺结节的临床和病理特点。方法回顾性分析本院2009年1月至2011年6月2843例河南地区汉族甲状腺结节患者病历资料。结果甲状腺结节高发年龄为45～54岁，其病理类型以单纯性结节性甲状腺肿为主（56．8％），手术误诊率为2．4％；22．1％的甲状腺结节患者可出现甲状腺功能异常，主要为亚临床甲状腺功能异常；同时，甲状腺结节患者TPOAb阳性率为19．8％，TgAb阳性率为20．0％。2843例甲状腺结节患者中分化型甲状腺癌（DTC）患者819例（28．8％），25～34岁及大于74岁患者中DTC的患病率均大于40％，DTC在甲状腺结节患者中患病率基本随TSH水平的升高而升高：TgAb阳性患者中DTC患病率最高（33．8％）。DTC患者与非DTC患者间TPO—Ab水平无明显差异（P=0．406），但DTC患者TgAb水平明显高于非DTC患者（P=0．033）。结论25—34岁及大于74岁的甲状腺结节患者是DTC的高发人群，血清TSH水平及TgAb水平与甲状腺结节患者的DTC发病风险呈正相关。
Objective To analyze the clinical and pathological characteristics of thyroid nodules. Methods A retrospective analysis of the clinical data of 2 843 Han patients with thyroid nodules fi＇om January 2009 to June 2011 in Henan province was performed. Results Tile most high-risk of thyroid nodule resided in the group aged 45- 54. The main pathological manifestation was simple nodular goiter. The rate of preoperative misdiagnosis was 2.4%. 22. 1% of the patients with thyroid nodules showed abnormal thyroid function, which was mainly as subclinical thyroid dysfunction. The positive rate of thyroid peroxidase antibody （TPOAb） in patients with thyroid nodule was 19.8% while that of thyroid globulin antibody （TgAb） was 20.0%. Among all 2 843 subjects, the prevalence of differentiated thyroid carcinoma （DTC） was 28.8% , and the incidence of DTC was accompanied by raised TSH levels. The prevalence of DTC exceeded 40% in patients aged between 25 to 34 as well as more than 74 years old. The prevalence of DTC was up to 33.8% in TgAb positive patients. There was no difference in TPOAb levels between DTC patients and non DTC patients （ P = 0. 406 ）, but the TgAb level in patients with DTC was significantly higher than that of non DTC patients （ P = 0. 033 ）. Conclusion Thyroid nodule patients aged 25-34 or older than 74 formed high-risk groups of DTC. The serum TSH level and TgAb level were positively correlated with the risk of DTC.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2012年第10期802-805,共4页
Chinese Journal of Endocrinology and Metabolism
