摘要
目的通过对385例甲状腺结节手术患者临床资料统计分析，比较不同因素与甲状腺良恶性结节的相关性。方法针对2010年1至6月本院普外科行甲状腺手术385例患者的临床资料、术后病理及甲状腺超声进行回顾性分析。结果（1）385例甲状腺手术患者中，良性结节组264例，占68．57％：恶性结节组121例，占31．43％。良性结节组平均年龄（48．1±13．4）岁，恶性结节组平均年龄（45．6±12．5）岁。（2）良性结节组与恶性结节组按照性别分组进行比较，两组男性女性比例无统计学差异（P〉0．05）。（3）依照体重指数进行分组，超重组甲状腺癌的比例最高，肥胖组次之。（4）良性结节组的空腹血糖均值（5．61±1．07）mmol／L，恶性结节组的空腹血糖均值（5．864-1．21）mmol／L（P〈0．05）。（5）良性结节组TSH为（1．62±1．30）mIU／L，恶性结节组为（2．02±2．59）mIU／L（P〈0．05）。（6）超声提示恶性结节组中形态不规则、边界不清、伴钙化及淋巴结转移的比例明显高于良性结节组（P〈0．05）．（7）Logistic回归分析结果显示血糖、年龄、甲状腺结节形态不规则，伴钙化、淋巴结转移，是甲状腺癌的危险因素。结论（1）甲状腺癌组的空腹血糖水平、TSH水平明显高于良性结节组。（2）年龄与甲状腺癌患病率负相关。（3）超声显示甲状腺结节形态不规则、伴钙化及淋巴结转移，提示甲状腺癌的可能性大。
Objective To analyze the clinical features of 385 postoperative thyroid nodules patients, and to compare the correlation affected by different factors between benign and malignant thyroid nodules. Methods Total 385 patients underwent thyroid operation in general surgery department of our hospital were enrolled. Their clinical data, ultrasonic scanning of thyroid, and pathological results were compared between benign and malignant thyroid nodules. Results （ 1 ）264 cases with benign nodules （68.57%） and 121 cases with malignant nodules （ 31.43% ） were found among 385 cases. The average age of benign group was （48.1 ± 13.4 ） years old, while malignant nodules group was （ 45.6 ± 12.5 ） years old. （ 2 ） No gender difference was found between benign and malignant nodules group （ P〉0.05 ）. （ 3 ） According to body mass index （ BMI）, the highest prevalence of lnalignant nodules was in overweight group, followed by obesity group. （ 4 ） Fasting blood glucose was （ 5.61 ± 1.07 ） mmol/L in benign group and （ 5.86 -＋ 1.21 ） mmol/L in malignant group （ P〈0.05 ）. （ 5 ） Thyroid-stimulating hormone （TSH） in benign nodules group was （ 1.62 ± 1.30 ） mlU/L, while in malignant nodules group, which was （ 2.02±2.59 ） mlU/L（ P〈0.05 ）. （ 6 ） Irregular shape, unclear boundary, calcification, and lymph node metastasis were more frequent in malignant group than those in benign group under ultrasonic scanning （ P〈0.05 ）. （7） Logistic regression analysis revealed that the existence of thyroid cancer was significantly associated with age, fasting blood glucose, ultrasonic images （ lymph node metastasis, irregular shape, and calcification）. Conclusion （ 1 ） Fasting blood glucose levels and TSH in the malignant nodules group are higher than those in the benign group. （ 2 ） A negative correlation exists between age and thyroid cancer prevalence. （3） Ultrasonic images, including lymph node metastasis, irregular nodule shape, and calcification, may suggest the high possibility of thyroid cancer.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2012年第10期806-810,共5页
Chinese Journal of Endocrinology and Metabolism
基金
辽宁省科技厅科学技术计划项目（2011225013）
关键词
甲状腺癌
年龄
血糖
促甲状腺素
超声
Thyroid cancer
Age
Blood glucose
Thyroid-stimulating hormone
Ultrasound
