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原发性颅内绒毛膜癌四例并文献复习 被引量:5

Primary intracranial choriocarcinoma (four cases report and literatures review )
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摘要 目的探讨原发性松果体区绒毛膜癌的临床特点、诊断、治疗方法及预后。方法回顾性分析北京天坛医院神经外科2002年5月至2010年5月收治的4例原发性松果体区绒毛膜癌患者的临床资料,复习相关文献,并对患者随访。结果4例患者均为男性,平均年龄13.75岁,病变均位于松果体区,平均直径4~5cm。3例术前行诊断性放疗,其中2例出现肿瘤卒中。采用经胼胝体一穹隆间入路切除肿瘤,其中全切3例,近全切除1例,术后均建议化疗。随访时间1个月一5年,3例死亡,1例存活,随访期内平均生存时间为31.7个月。结论原发性松果体区绒毛膜癌极为罕见,预后极差。血清或脑脊液人绒毛膜促性腺激素(13-HCG)明显升高有助于诊断。手术切除联合化疗是常规治疗方法,放疗因增加出血风险,瘤体较大时,不建议作为常规辅助治疗。 Objective To investigate the clinical features, diagnosis, therapeutic strategy and prognosis of Primary Intracrauial Choriocarcinoma (PICCC). Methods A retrospective review of four patients with PICCC diagnosed histopathologically was performed during May 2002 to May 2010, and all patients were followed up and pertinent literatures were reviewed. Results There were four young male children studied. The average age of all patients was 13.75 years. Everyone had a mass lesion in pineal region where its average diameter was 4 ~ 5 cm. Three cases were given preoperative diagnostic irradiation, of which two cases had hemorrhage after irradiation. All received operation with trans - corpuscallosum - fornix approach, three cases received total resection, and the other one had subtotal resection. After operation, all cases were supposed to have chemotherapy. 3 patients died finally during a follow - up period range from 1 month to 5 years with chemotherapy, and the mean survival time was 31.7 months. Conclusions PICCC are extremely rare and the most malignant of primary intracranial GCTs, patients have poor prognosis. Markedly elevated 13-HCG levels in serum or cerebrospinal fluid are strongly suggested to be found with PICCC while mild elevations can be seen with other GCTs. The authors recommend surgery for patients with PICCC combined with chemotherapy. Radiotherapy is not the conventional therapy due to the increasing risk of hemorrhage.
出处 《中华神经外科杂志》 CSCD 北大核心 2012年第10期987-990,共4页 Chinese Journal of Neurosurgery
关键词 绒毛膜癌 肿瘤 生殖细胞和胚胎性 诊断 化学疗法 外科手术 Choriocarcinomas Neoplasms,germ cell and embryonal Diagnosis Chemotherapy Surgical procedures ,operative
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参考文献19

  • 1Shinoda J, Sakai N, Yano H, et al. Prognostic factors and thera- peutic problems of primary intracranial chofiocarcinoma/germ - cell tumors with high levels of HCG. J Neurooncol, 2004, 66 : 225-240.
  • 2Kyritsis AP. Management of primary intracranial germ cell tumors. J Neurooncol, 2010, 96: 143-149.
  • 3Kageji T, Nagahiro S, Matsuzaki K, et al. Successful neoadjuvant synchronous chemo - and radiotherapy for disseminated primary intracranial choriocarcinoma: case report. J Neurooncol, 2007, 83: 199-204.
  • 4Bjomsson J, Scheithauer BW, Leech RW. Primary intracranial choriocarcinoma: a case report. Clin Neuropathol, 1986, 5: 242 -245.
  • 5Koyama S, Tsubokawa T, Katayama Y, et al. Choriocarcinomaof the septum pellucidum: case report. Surg Neurol, 1991, 35: 478-482.
  • 6Teilum G, Albrechtsen R, Norgaard -Pedersen B. The histog- enetic - embryologic basis for reappearance of alpha - fetoprotein in endodermal sinus tumors (yolk sac tumors) and teratomas. Acta Pathol Micrebiol Scand A, 1975, 83 : 80-86.
  • 7Harms D, Janig U. Germ cell tumours of childhood. Virchows Archiv, 1986, 409: 223-239.
  • 8Hongo T, Fujii Y, Fukuoka T, et al. Long - term treatment in infantile choriocarcinoma. Acta Paediatr Jpn, 1992, 34 : 52-59.
  • 9郑金锋,马淑芳,胡维诚.痤疮患者血浆雄激素水平及白细胞雄激素受体的测定[J].临床皮肤科杂志,2002,31(6):363-364. 被引量:17
  • 10Kawakami Y, Yamada O, Tabuchi K, et al. Primary intracranial chorioearcinoma. J Neurosurg, 1980, 53: 369-374.

二级参考文献38

  • 1崔竹梅,杨秀玉,向阳,宋鸿钊,邵丽娜,李大兵.足月产后绒癌误诊分析[J].中国妇产科临床杂志,2001,2(1):22-24. 被引量:8
  • 2冷金花,杨秀玉,杨宁,宋鸿钊,岳天孚.选择性盆腔动脉插管化疗致附壁血栓形成[J].中华妇产科杂志,1995,30(4):218-221. 被引量:10
  • 3赵瑛,刘志民,邵福源,吴萍嘉.人外周血白细胞雄激素受体的鉴定及意义[J].中华核医学杂志,1995,15(1):51-52. 被引量:39
  • 4杨秀玉,宋鸿钊.滋养细胞疾病诊断与治疗中的问题及对策[J].中华妇产科杂志,1996,31(4):195-198. 被引量:49
  • 5白广明 罗世祺 李德泽 等.儿童松果体区肿瘤[J].中华外科杂志,1981,19:216-219.
  • 6罗世祺 李德泽 白广明 等.经幕下小脑上入路切除儿童松果体区肿瘤[J].中华外科杂志,1982,20:184-185.
  • 7罗世祺 李德泽 王忠诚 等.儿童及第三脑室后部肿瘤的手术治疗[J].中华神经精神疾病杂志,1983,9:129-131.
  • 8[4]Willians S,Blessing JA,Liao SY,et al.Adjuvant therapy of ovarian germ cell tumors with cisplatin,etoposide,and blemycin:A trial of the Gynecologic Oncology Group.J Clin Oncol,1994,12:701 ~ 706.
  • 9Schmidek HH.Management of pineal region neoplasms.In: Shimidek HH, Sweet WH, eds. Operative neurosurgical techniques. 4rd ed.Philadelphia: WB Saunders, 2000. 891-894.
  • 10Sano K. Alternate surgical approaches to pineal region neoplasms.In: Shimidek HH, Sweet WH, eds. Operative neurosurgical techniques. 4rd ed. Philadelphia: WB Saunders, 2000. 895-907.

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