摘要
为探讨脐血 (cordblood ,CB)对急性髓系白血病 (ALL)强烈化疗后骨髓抑制期的辅助及支持治疗作用 ,用密闭式采血法采集CB ,一个胎盘所采集CB为 1个单位。对 42例AML患儿采用HAE/DAE方案化疗 ,其中治疗组在强烈化疗后 ,短期内多个CB连续输注 ,平均 4～ 5个单位CB。结果治疗组骨髓抑制期天数短于对照组 (P<0 .0 1 ) ,骨髓抑制程度治疗组较轻 ,治疗组血小板和中性粒细胞相对较高 (P <0 .0 1 ) ,并且治疗组感染和出血发生率低于对照组 (P <0 .0 1 )。另外 ,输注CB治疗组缓解率高于对照组 (P <0 .0 5 )。结果表明 ,CB输注对AML强化疗后的骨髓抑制有明显的恢复作用 ,可以减轻骨髓抑制程度 ,缩短骨髓抑制期 ,从而减少化疗后感染出血发生率 ,并有助于AML达到完全缓解 ,CB输注治疗白血病是一种有效的辅助及支持疗法 。
Objective: To observe the effect of cord blood (CB) in children with acute myeloid leukemia (AML) in period of post chemotherapeutic bone marrow suppression. Methods: Closed collection systems have been principally used by designated CB collection centers with trained staff. Forty-two children patients with newly diagnosed AML were treated with HAE/DAE regimen. The infusion of numbers of CB in patients with AML in period of post chemotherapeutic bone marrow suppression. Results and Conclusion: the results showed that infusion of numbers of CB in AML the interval period of chemotherapy in might significantly reduce the infection and the amount of blood of infusion, and it was helpful to get and also to elevate the rate o complete remission in AML. It suggests that CB may promote hematopoitic recovery in patients with AML received extensive chemotherapy. Therefore , we believed that infusion of CB was an important metnods as to be support therapy.
出处
《中国小儿血液》
2000年第4期162-164,共3页
China Child Blood
