摘要
目的 观察急性心肌梗死后心室结构的主要变化及心肌局部血管紧张素Ⅱ和羟脯氨酸含量的变化 ,并观察黄芪的治疗作用。方法 采用兔制备心肌梗死模型 ,黄芪组自术后第二日腹腔注射黄芪 2～ 3ml,每日二次 ,共三周。于术后第六周处死动物 ,用精确天平及精密卡尺直接测量左室重量、全心重量及梗死区、游离壁和室间隔厚度。采集标本 ,检测梗死区、游离壁及正常兔心肌血管紧张素Ⅱ和羟脯氨酸含量。结果 梗死后全心重量及左室重量均增加 ,差异显著 ,室间隔及游离壁厚度增加 ,梗死区室壁变薄 ,差异显著 ;心肌梗死后心肌局部血管紧张素Ⅱ含量显著增加 ,梗死区羟脯氨酸含量显著增加 ,游离壁羟脯氨酸含量略有增加 ;经黄芪治疗后左室重量和全心重量均下降 ,其中全心重量尚未恢复至正常 ;心肌血管紧张素Ⅱ含量明显下降 ,梗死区羟脯氨酸含量略有下降。结论 心肌梗死后心室构型发生明显变化 ,血管紧张素Ⅱ和羟脯氨酸参与左室重构 ,黄芪有一定的治疗作用。
Objective Observe the main changes of ventricular changes and the content of Angiotensin Ⅱ (Ang Ⅱ),Hydroxyproline (HP) in local myocardium after myocardial infarction,study the theraputic effects of Radix Astragali on left ventricular remodeling.Methods Sixty rabbits were randomized into three groups:normal group including 20 rabbits,experimental AMI control group including 20 rabbits and AMI Radix Astragali treated group.All animals were killed in the sixth week after coronary ligation.Left ventricular mass,thickness of infarcted and non-infarcted zone were directly measured.The content of Ang Ⅱ and HP in local myocardium was also measured.Results The LV mass was increased( P <0.05),infarcted zone became thinner( P <0.01),non-infarcted zone became thicker( P <0.01),the content of Ang Ⅱ and HP were increased.All these were improved in the Radix Astragali-treated group.Conclusion The structural changes after myocardial infaretion were remarkable,Ang Ⅱ and interstitial matrix play an important role in these changes.Radix Astragali can attenuate left ventricular remodeling. [
出处
《中国急救医学》
CAS
CSCD
北大核心
2000年第7期381-383,共3页
Chinese Journal of Critical Care Medicine
关键词
急性心肌梗塞
左室重构
黄芪
中医药疗法
Myocardial infarction
Left ventricular remodeling
Angiotensin Ⅱ
Hydroxyproline
Radix Astragali
