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初发2型糖尿病外周血miR-9,miR-124表达及其临床意义初探 被引量：2

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摘要 提取44例2型糖尿病、31例健康志愿者(正常糖耐量组)外周血单个核细胞;Trizol法提取总RNA;时实荧光定量(染料法)PCR方法检测miR-9、miR-124和PPARα mRNA表达水平。结果与正常糖耐量组比较,初发2型糖尿病患者血清甘油三酯水平升高(P<0.01),伴随miR-9表达上调123.65%(P=0.0 00);miR-124表达上调49.51%(P=0.005);PPARα mRNA表达下调42.08%(P=0.029)。结论初发2型糖尿病患者血清甘油三酯显著性升高,伴随外周血miR-9和miR-124高表达而PPARα低表达。
作者 郭东更 田文真 刘思阳 卢晓航 李红梅
机构地区 宁夏人民医院内分泌科
出处 《实用糖尿病杂志》 2012年第5期49-51,共3页 Journal of Practical Diabetology
关键词 2型糖尿病 PPARΑ MIR-9 miR-124
分类号 R587.1 [医药卫生—内分泌]
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实用糖尿病杂志
2012年 第5期

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