摘要
目的探讨补体C3、补体C4、抗甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)和促甲状腺激素受体刺激抗体(TSAb)检测对桥本甲状腺炎(HT)的诊断价值和病情发展判定的意义。方法选择HT患者120例作为HT组,同期就诊的Graves病患者110例作为Graves’病组,30例健康体检者作为对照组。3组患者分别检测补体C3、补体C4、TGAb、TPOAb和TSAb,并进行比较。结果 HT组和Graves病组TGAb、TPOAb和TSAb水平和阳性率较对照组明显升高,HT组TGAb和TPOAb的水平和阳性率升高较Graves病组升高更为明显,而TSAb的水平和阳性率Graves病组较HT组更为明显。HT组的补体C3和补体C4水平较对照组和Graves病组明显降低,而对照组和Graves病组无显著性差异。HT组中甲减亚组补体C3和补体C4水平的变化较甲功正常亚组和甲功亢进亚组明显降低。结论 HT是最常见的自身免疫性甲状腺疾病之一,因其血清学诊断标准不具特异性,联合检测补体C3、补体C4和甲状腺自身抗体对提高HT的临床诊断以及判断病情发展具有较重要的临床意义。
Objective It is to explore the significance of complement C3, complement C4, anti-thyroglobulin antibody （TGAb） , thyroid peroxidase antibody （TPOAb） and TSH receptor stimulating antibody （TSAb） in the diagnosis and prognostic evaluation of Hashimoto thyroiditis（HT）. Methods 120 cases of patients with HT were chosen as HT group, 110 cases of Graves disease in the same period were chosen as Graves group and 30 health examination people were selected as control group. The complement C3 , complement C4 , TGAb and TPOAb in each group were detected and compared. Results The levels and positive rates of TGAb, TPOAb and TSAb in HT group and Gravesdiseases group were significantly higher than those in control group （P 〈 0.01 ） , the levels and positive rate of TGAb and TPOAb in HT group increased more significantly compared with the Graves diseases group, while the levels and positive rate of TSAb in Graves diseases group increased more significantly compared with the HT group . The levels of complement C3 and C4 in HT group were lower significantly than those in control group and Graves diseases group, the difference was statistically significant, while there was no significant difference between Graves diseases group and control group. The levels of complement C3 and C4 in hypothyroidism subgroup were lower significantly than those in the normal thyroid function subgroup and the hyperthyroidism subgroup from HT group, the difference was statistically significant（P 〈 0.05 ）. Conclusion HT is the most common autoimmune thyroid diseases. Because of serum diagnosis standard without specificity, combined detection of complement C3, C4 and thyroid autoantibodies have certain clinical value for diagnosis and prognostic evaluation for HT.
出处
《现代中西医结合杂志》
CAS
2012年第32期3541-3543,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
