摘要
肠集聚性大肠杆菌(enteroaggregative Escherichia coli,EAEC)是一类新发现的致泻性大肠杆菌。该菌目前已在世界各发达、发展中国家出现散发或暴发流行。我国虽尚未报道EAEC的散发或暴发,但仍需给予足够重视。EAEC的致病机制相对复杂,且不同菌株基因组异质性(多态性)较大,其感染后的临床表现不一,诊断治疗更要综合考虑多方面的因素。本文将从EAEC的流行病学特征、致病机制、临床表现、诊断和治疗等方面,对这一新发的肠道病原体做一综述。
Enteroaggregative Escherichia coli （EAEC） is an emerging diarrheal pathogen. EAEC has caused sporadic infections and outbreaks in both developing and developed countries. We should pay more attention to this pathogen though no EAEC infection has been reported in our country. The pathogenesis of EAEC is complicated, and the strains are highly heterogeneous （polymorphic）. The clinical manifestations are various and many factors influence the diagnosis and treatment of EAEC infection. This paper will summarize the pathogenesis of EAEC and the epidemiological characteristics, clinical manifestation and diagnosis/treatment of EAEC infection.
出处
《疾病监测》
CAS
2012年第10期828-833,共6页
Disease Surveillance
基金
"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项(No.2011ZX10004-001)~~
关键词
肠集聚性大肠杆菌
流行病学
毒力因子
致病机制
enteroaggregative Escherichia coli
epidemiology
virulence factor
pathogenesis
