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E-钙黏蛋白与核因子κB在食管鳞癌中的表达及意义

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摘要 目的检测E-钙黏蛋白(E-cadherin)与核因子κB(NF-κB)在食管鳞状细胞癌及癌旁正常食管鳞状上皮中的表达差异。方法应用免疫组化S-P方法检测40例食管鳞状细胞癌及其癌旁正常食管鳞状上皮中E-cadherin与NF-κB的表达情况。结果 E-cadherin在癌旁正常食管鳞状上皮中27例(67.5%)呈阳性表达,在食管鳞状细胞癌中11例(27.5%)呈阳性表达,差异有统计学意义(P<0.05)。食管鳞状细胞癌E-cadher-in表达下降与患者的年龄、性别无关(P>0.05),与分化程度、TNM分期及淋巴结转移有关(P<0.05)。NF-κB在食管癌旁正常食管鳞状上皮中12例(30.0%)呈阳性表达,在食管鳞状细胞癌中26例(65.0%)呈阳性表达,差异有统计学意义(P<0.05)。食管鳞状细胞癌NF-κB表达升高与患者的年龄、性别及分化程度无关(P>0.05),与TNM分期和淋巴结转移有关(P<0.05)。E-cadherin与NF-κB蛋白表达呈负相关关系(r=-0.517,P<0.05)。结论 E-cadherin蛋白在食管鳞状细胞癌中的表达有不同程度下降,而NF-κB蛋白在食管鳞状细胞癌中的表达有不同程度上调,两者可能在食管癌的发展过程中起着重要作用。它们可能是食管鳞癌中的重要分子标记物,有望成为食管癌早期诊断、治疗以及预测食管癌患者预后的具有重要应用价值的指标。
出处 《广东医学》 CAS CSCD 北大核心 2012年第20期3122-3124,共3页 Guangdong Medical Journal
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