摘要
目的比较人工泪液和人工泪液联合性激素两种方法治疗围绝经期妇女干眼症的临床效果。方法选择巨野县人民医院2009年1月至2011年1月诊治的符合围绝经期诊断标准的干眼症患者66例，随机分为两组，对照组33例给予人工泪液治疗，观察组33例给予人工泪液联合性激素（含雌孕激素及雄激素之复合制剂）治疗，两组均定期随访6-12个月。结果观察组总有效率为96．97％，优于对照组的72．73％，两组比较差异有统计学意义（P〈0．05）；治疗1年后泪膜破裂时间检查（BUT）显示有效（延长≥1s）：观察组30例（90．91％），对照组25例（75．76％）；显效（延长≥3s）：观察组24例（72．73％），对照组18例（54．55％），两组间比较差异有统计学意义（P〈0．05）。结论人工泪液联合性激素（含雌、孕激素及雄激素之复合制剂）治疗围绝经期干眼症，其临床效果优于单纯用人工泪液治疗，值得临床推广应用。
Objective To compare the pausal women with xerophthalmia. Methods clinical effect of the two treatment methods on perimeno- Sixty-six cases with xerophthalmia from January 2009 to January 2011 were randomly divided into two groups, 33 patients in the control group were given artificial tears therapy, 33 cases in the observation group were treated with artificial tears combined with sex hor- mones （estrogen and progesterone, androgen compound preparations）, both groups were regularly fol- lowed up for 6 to 12 months. Results The totat effective rate in the observation group was 96.97%, which was better than that in the control group （ 72.73% ） , the difference was statistically significant （ P 〈 0. 05 ） ; 1 year later, BUT was shown to be effective （ extension ≥1 s） ： 30 cases （90. 91% ） in the observation, 25 cases in the control group （75.76%）; be significant effective （to extend ≥ 3 s）： 24 cases （72.73%） in the observation group, 18 cases （54.55%） in the control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusions The clinical effect of artificial tears combined with sex hormones （including estrogen, progesterone, androgen compound preparations） treatment was better than simply using artificial tears therapy, and it is worthy of clinical application.
出处
《中国实用医刊》
2012年第22期45-47,共3页
Chinese Journal of Practical Medicine
