摘要
目的研究芦丁对糖尿病肾病(diabetic nephropathy,DN)大鼠的保护作用。方法采用腹腔注射链脲霉素(strepto-zotocin,STZ)的方法复制DN大鼠模型,分为正常组(NS组),DN模型组(DN组)、芦丁低剂量治疗组(RL组,10mg/kg)、芦丁中剂量治疗组(RM组,30mg/kg)、芦丁高剂量治疗组(RH组,90mg/kg)、卡托普利对照组(CAP组,剂量为10mg/kg),每组10只,灌胃给药,12周后测定空腹血糖、尿白蛋白、肾脏指数、尿素氮、肌酐、观察肾脏组织形态学改变。结果芦丁能明显改善糖尿病肾病模型大鼠的血糖(Glu)、24h尿白蛋白、肾脏指数、尿素氮、肌酐以及肾小球组织形态。结论芦丁对糖尿病肾病大鼠具有好的保护作用。
Objective To study rutin＇s preventive and therapeutic effects on early stage of diabetic nephropathy （DN） in rats. Methods The DN rats model was established by intraperitoneal injection of streptozotocin. Then rats were randomly divied 6 groups： nor- mal group（NS） , DN model group, low dose of rutin group （RL, 10mg/kg） , moderate dose of rutin group （RM, 30mg/kg） , high dose of rutin group （ RH, 90mg/kg） , and captopril group （ CAP, 10mg/kg）. Every group was housed in a SPF environment suitable for breed- ing specific pathogen -free grade animals for 12 weeks, and they were allowed free access to food and water. Finally the leves of blood glucose （Glu） , urine protein, ereatinine （Cr） and blood urea nitrogen （BUN） were detected. Renal morphological changes were observed by HE dyeing method. Results The Glu, 24h urine protein, kidney index, BUN, Cr and glomerular morphology of DN rat were all im- proved significantly after being administrated rutin. Conclusion Rutin has the protective effects on early stage of diabetic nephropathy （DN） in rats.
出处
《医学研究杂志》
2012年第10期144-148,共5页
Journal of Medical Research
关键词
糖尿病肾病
芦丁
大鼠
保护作用
Diabetic nephropathy （DN）
Rutin
Rat
Protective effects
