摘要
目的:观察清肺保元汤联合西医治疗对重症肺炎患者血清IL-2、IL-6、IFN-γ水平的影响。方法:将重症肺炎患者41例随机分为治疗组(T组)21例,对照组(C组)20例。C组按重症肺炎指南进行常规西医治疗。T组在C组治疗的基础上加用清肺保元汤。于治疗前(第0天)和治疗后第21天分别进行重症肺炎证候评分,计算T组及C组治疗有效率,并分别检测患者血清中干扰素-γ(IFN-γ)、白介素-2(IL-2)、白介素-6(IL-6)水平。结果:第0天时,T组及C组重症肺炎证候评分,血清IFN-γ、IL-2、IL-6水平无差别;第21天,C组死亡1例,无效2例;T组无死亡病例,无效2例,T组有效率较C组有所提高(91%vs 85%),但两组对比无统计学差异。T组及C组证候评分下降,但两组间对比无差别;T组及C组血清IFN-γ、IL-2、IL-6水平均下降,且T组与C组相比下降更为明显(P<0.05)。结论:清肺保元汤联合西医治疗更能有效抑制重症肺炎患者IFN-γ、IL-2、IL-6过度分泌,从而缓解炎症反应,促进疾病恢复。
Objective： To observe the effect of Qingfeibaoyuan Decoction combined western treatment on serum IL-2,IL-6,and IFN-γin severe pneumonia（SP） patients.Methods： 41 SP patients had been randomly divided into the traditionalwestern combined treatment group（Tgroup,21 cases） and the control group（C group,20 cases）.Patients in two groups were cured following the guideline of SP,and the patients in T group added Qingfeibaoyuan Decoction.We named the day before treatment in 0 day.On the 0 and 21th day,the pneumonia scores of every patient that were related the severity of their diseases were counted,which helped us to calculate effective rate of the two groups.At the same time,serum IL-2,IL-6 and IFN-γwere detected by ELISA.Results： On the 0 day,there were no significant difference of pneumonia scores and serum IL-2,IL-6,IFN-γ in the two groups.On the 21th day,one patient died in C group,whereas no patient died in T group,the effect rate in T group was higher than that in C group（91% vs 85%）,but there was no statistical difference in the two groups.Pneumonia scores were lower but there was no significant difference in the two groups.And serum IL-2,IL-6 and IFN-γwere all decreased,more importantly,which were lower in the T group than that in C group（P0.05）.Conclusion： Compared with the western treatment,Qingfeibaoyuan Decoction combined western treatment could have more effect to rebalance the immune system with the down-regulation of proinflammatory cytokines such as serum IL-2,IL-6 and IFN-γ,which might be a new measurement in treating severe pneumonia.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第11期3000-3003,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
贵州省中医药管理局中医药
民族医药科学技术课题研究资助项目(No.QZYY2010-20)~~
