摘要
目的观察低分子肝素钙联合地奥司明防治静脉曲张术后下肢深静脉血栓形成的临床疗效。方法选取2009年10月至2011年10月静脉曲张患者206例,分为治疗组和对照组,各103例。所有患者均行大隐静脉高位结扎剥脱术。治疗组术前4h给予脐周皮下注射低分子肝素钙及口服微粒化地奥司明片,且术后维持口服1周;对照组术前4 h给予脐周皮下注射低分子肝素钙。术后两组均给予脐周皮下注射小剂量低分子肝素钙。观察两组术前、术后1周小腿周径,B超检查有无深静脉血栓,血液生化检查及不良反应发生情况。结果术后1周,对照组小腿周径较术前明显增加(t=11.725,P<0.001),也较同期治疗组粗(t=9.601,P<0.001);B超检查发现对照组术后下肢深静脉血栓总发生率显著高于同期治疗组(矫正χ2=8.199,P<0.05)。结论低分子肝素钙联合地奥司明在降低下肢深静脉血栓发生率方面更有优势,疗效确切且不良反应少,可作为临床防治大隐静脉曲张术后深静脉血栓形成的药物治疗方案。
Objective To investigate the clinical efficacy of low molecular weight heparin calcium （LMWH） combined with diosmin in preventing postoperative lower limb deep venous thrombosis （LDVT） in varicosis of great saphenous vein. Methods Two hnndred and six patients with varicosis of great saphenous vein from October 2009 to October 2011 were selected and divided into the treatment group and the control group with 103 cases in each group. All the cases were performed the great saphenous vein high ligation and exfoliation. The treatment group was given LMWH by periumbilical subcutaneous injection at preoperative 4 h, and oral micronized dios-min, which maintained for postoperative 1 week. The control group was given LMWH by periumbilical subcutaneous injection at preoper-ative 4 h. Small dose of LMWH was given by periumbilical subcutaneous injection after operation in both two groups. The shank circum- ference in preoperation and postoperative 1-week was observed and type-B ultrasound was conducted to determine whether LDVT oc-curred. The blood biochemical detections were performed and the adverse reactions were observed. Results The postoperative 1-week shank circumferences in the control group were significantly increased than preoperation（ t = 11. 725, P 〈 0. 001）, and were thicker than those in the treatment group（t =9. 601, P〈0. 001）. The type-B ultrasound examination revealed that the total incidence rate of postop- erative LDVT in the control group was significantly higher than that in the treatment group（correction X^2 = 8. 199, P 〈 0. 05）. Conclusion LMWH combined with diosmin shows obvious superiority in decreasing the incidence rate of LDVT with definite efficacy and without adverse reactions, which may be used the medication regimen for preventing postoperative LDVT in varicosis of great saphenous vein.
出处
《中国药业》
CAS
2012年第21期66-67,共2页
China Pharmaceuticals
关键词
低分子肝素钙
地奥司明
大隐静脉曲张术
下肢深静脉
血栓
low molecular weight heparin calcium
diosmin
varicosis of great saphenous
lower limb deep vein
thrombosis
