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Th9细胞参与MS和EAE发病机制的研究进展 被引量：4

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摘要 学术界普遍认为Th1/Th2和Th17/Treg轴在多发性硬化（Multiple sclerosis,MS）的发病机制中起主要作用。然而,随着免疫学研究的不断发展,我们对于MS免疫学发病机制的认识也不断深入。2008年,Natural immunology上先后刊载了两篇文章,报道了一群能分泌IL-9和IL-10的新型效应性T淋巴细胞亚群,即Th9细胞[1,2]。
作者 徐文 胡学强
机构地区 中山大学附属第三医院神经病学科
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2012年第10期949-952,共4页 Chinese Journal of Immunology
基金 国家自然科学基金资助项目(No.81171126)
关键词 免疫学发病机制 T淋巴细胞亚群 MS EAE TH1/TH2 多发性硬化 IL-10 学术界
分类号 R744.5 [医药卫生—神经病学与精神病学]
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参考文献44

  • 1Dardalhon V, Awasthi A, Kwon H et al. IL-4 inhibits TGF-beta-in?duced Foxp3 + T cells and, together with TGF -beta, generates IL-9 + IL-I0 + F oxp3 ( -) effector T cells [J]. Nat Immunol, 2008; 9 ( 12) : 1347 -1355.
  • 2Veldhoen M, Uyttenhove C, van Snick J et al. Transfonning growth factor-beta reprograms' the differentiation of T helper 2 cells and pro?motes an interleukin 9-producing subset [ J]. Nat Immunol, 2008; 9 ( 12) : 1341 -1346.
  • 3Ciprandi G, De Amici M, Castellazzi A M et al. Serum IL-9 levels depend on allergen exposure: preliminary study [J]. Int Arch Allergy Immunol, 2011 ; 154(3) :246-248.
  • 4Chang He, Sehra S, Goswami R et al. The transcription factor PU. 1 is required for the development of IL-9 -producing T cells and aller- gic inflammation [ J]. Nat Immunol , 2010; 11 (6) :527 -534.
  • 5Chang H C, Zhang S, Thieu V T et al. PU. 1 expression delineates heterogeneity in primary Th2 cells [ J]. Immunity, 2005; 22 (6) : 693-703.
  • 6Staudt V, Bothur E, Klein M et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells [ J]. Im?munity, 2010; 33 (2) : 192-202.
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  • 8Renauld J C, Goethals A, Houssiau F et al. Human P40/IL-9. Ex?pression in activated CD4 + T cells, genomic organization, and com?parison with the mouse gene [ J]. J Immunol, 1990; 144 ( 11 ) : 4235- 4241.
  • 9Kennouni A, Van Roost E, Arden K C et al. The IL-9 receptor gene ( IL9 R) : genomic structure, chromosomal localization in the pseudo?autosomal region of the long arm of the sex chromosomes, and identifi?cation of IL9R pseudogenes at 9qter, IOpter , 16pter, and 18pter [J]. Genomics, 1995; 29 (2) :371-382.
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同被引文献90

  • 1Sheng-Nan Peng,Hui-Hong Zeng,Ai-Xiang Fu,Xiao-Wen Chen,Qing-Xian Zhu.Effects of rhein on intestinal epithelial tight junction in IgA nephropathy[J].World Journal of Gastroenterology,2013,19(26):4137-4145. 被引量：13
  • 2Veldhoen M,Uyttenhove C,van Snick J,et al.Transforming growth factor-beta'reprograms'the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset[J].Nat Immunol,2008,9(12):1341-1346.
  • 3Dardalhon V,Awasthi A,Kwon H,et al.IL-4 inhibits TGF-betainduced Foxp3+T cells and,together with TGF-beta,generates IL-9+IL-10+Foxp3(-)effector T cells[J].Nat Immunol,2008,9(12):1347-1355.
  • 4Kaplan MH.Th9 cells:differentiation and disease[J].Immunol Rev,2013,252(1):104-115.
  • 5Blom L,Poulsen BC,Jensen BM,et al.IL-33 induces IL-9 production in human CD4+T cells and basophils[J].PLo S One,2011,6(7):e21695.
  • 6Chang HC,Sehra S,Goswami R,et al.The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation[J].Nat Immunol,2010,11(6):527-534.
  • 7Staudt V,Bothur E,Klein M,et al.Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells[J].Immunity,2010,33(2):192-202.
  • 8Goswami R,Jabeen R,Yagi R,et al.STAT6-dependent regulation of Th9 development[J].J Immunol,2012,188(3):968-975.
  • 9Tan C,Aziz MK,Lovaas JD,et al.Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site[J].J Immunol,2010,185(11):6795-6801.
  • 10Putheti P,Awasthi A,Popoola J,et al.Human CD4memory T cells can become CD4+IL-9+T cells[J].PLo S One,2010,5(1):e8706.

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中国免疫学杂志
2012年 第10期

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