摘要
目的探讨梅毒螺旋体血清学联合检测的临床价值。方法采用甲苯胺红不加热血清试验(TRUST)、梅毒抗体-酶联免疫吸附试验(TP-ELISA)、荧光梅毒螺旋体吸收试验(FTA-ABS)对非梅毒感染者784例,既往梅毒感染已经治愈者268例,梅毒在体内活跃、危害人体者65例,梅毒早期感染者43例,梅毒假阳性者24例进行梅毒血清学检测并以组合方式进行分析。结果 TRUST阴性+TP-ELISA阴性或TRUST阴性+FTA-ABS阴性组合,非梅毒感染组的临床符合率为97.9%;TRUST阳性+TP-ELISA阴性或TRUST阳性+FTA-ABS阴性组合,梅毒假阳性组的临床符合率95.8%;TRUST阴性+TP-ELISA阳性组合,既往梅毒感染并已经治愈组的临床符合率为94.0%;TRUST阳性+TP-ELISA阳性组合,梅毒在体内活跃、危害人体组的临床符合率为98.5%;TRUST阴性+FTA-ABS阳性组合的梅毒早期诊断的临床符合率为95.3%;TRUST阳性+FTA-ABS阳性+TP-ELISA阴性3组组合梅毒早期诊断价值最高,临床符合率为97.7%;TRUST阳性+FTA-ABS阳性+TP-ELISA阳性3组组合梅毒早期感染的可能性小,临床符合率为4.6%。梅毒血清学检测的组合顺序反映不同的临床特征。结论梅毒血清学联合检测可互补单一血清诊断方法的不足,正确评价梅毒的临床状态,对梅毒的诊断与病情的观察有一定的临床价值。
Objective To Investigate the clinical value of detection of treponema pallidum with serology combination.Methods 784 patients with non-syphilis and 268 patients with syphilis been cured,65 cases with syphilis activin,43 cases of early syphilis and 24 cases with false-positive of syphilis were detected by serologic test and analyzed in combination that was toluidine red unheated serum reagin test（TRUST）,TP enzyme-linked immunosorbent assay（TP-ELISA） and Fluorescent treponema antibody absorption test（FTA-ABS）.Results The clinical coincidence rate was 97.9% in the non-syphilis infection regarded in the combination of TRUST negative and TP-ELISA negative,or TRUST negative and FTA-ABS-negative.While the clinical coincidence rate of 95.8% in false-positive by the combination of TRUST positive,TP-ELISA negative or TRUST positive and FTA-ABS negative,and it was 94% in syphilis cured and early infection,however,the clinical coincidence rates were 98.5%（active syphilis with TRUST positive and FTA-ABS positive）,95.3%（diagnosis for syphilis with TRUST negative and FTA-ABS positive）,97.7%（the highest value for early diagnosis with TRUST positive,FTA-ABS positive and TP-ELISA negative） and 4.6%（the minimum possibility used to early infection with TRUST positive,FTA-ABS positive and TP-ELISA positive）.Conclusion Syphilis serology combined detection can have correct evaluation of syphilis clinical state,there is of certain clinical value on the diagnosis of syphilis and pathogenetic condition observation.
出处
《检验医学与临床》
CAS
2012年第21期2690-2691,共2页
Laboratory Medicine and Clinic
