摘要
目的调查医院大肠埃希菌感染的临床分布及耐药性,为临床合理使用抗菌药物提供科学依据。方法对520株临床分离的大肠埃希菌对药物敏感试验结果进行回顾性分析。结果大肠埃希菌感染的部位主要见于伤口、泌尿道、呼吸道、血液、引流液等;大肠埃希菌耐药率低的抗菌药物是亚胺培南、美罗培南;阿米卡星、哌拉西林/他唑巴坦、头孢哌酮/苏巴坦耐药率小于或等于10%;对氟喹诺酮类及头孢菌素耐药率较高。结论治疗大肠埃希菌感染时,需根据药敏试验结果及患者病情选用碳青霉烯类、氨基糖苷类、β-内酰胺类抗菌药物/β-内酰胺酶抑制剂等。
Objective To investigate the clinical distribution of the infection by E.coli and the antimicrobial resistance,so as to provide scientific basis for reasonable clinical use of antibiotics.Methods Microbial sensitivity tests of 520 E.coli strains collected from the patients were reviewed and analyzed.Results The infection sites by E.coli mainly included wound,urinary system,respiratory system,blood,drainagliquid and so on.The resistance rates of E.coli to imipenem/cilastatin,meropenem,amikacin,cefoperazone/sulbactam and piperacillin/tazobactam were low（≤10%）,but rates to quinolones and cephalosporins were relatively high.Conclusion It should choose carbopenems,aminoglycosides,β-lactam/β-lactamase inhibitor combinations,etc,on the basis of microbial sensitivity tests and the patient′s condition when treating the infection by E.coli.
出处
《检验医学与临床》
CAS
2012年第21期2692-2693,共2页
Laboratory Medicine and Clinic
关键词
大肠埃希菌
临床分布
耐药性
产超广谱Β-内酰胺酶
escherichia coli
clinical distribution
antimicrobial resistance
extended-spectrum-β-lactamase
