摘要
以苯甲酸为起始原料 ,经溴化、Friedel crafts反应、Grignard反应制得 3 乙酰基二苯酮 (5 ) 。
Ketoprofen was synthesized from benzoic acid by bromination,the Friedel Crafts reaction,and the Grignard reaction to give 3 acetyl benzophenone,which was converted to ketoprofen via the Darzens reaction.The overall yield was 32%.
出处
《中国药物化学杂志》
CAS
CSCD
2000年第2期127-128,共2页
Chinese Journal of Medicinal Chemistry
