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2型糖尿病与8羟基脱氧鸟苷 被引量:1

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摘要 2型糖尿病(T2DM)的发病机制主要为胰岛素抵抗(IR)及β细胞功能受损两方面,目前认为只有IR不足以引发DM而需同时有β细胞功能受损,IR为始动因子,β细胞功能异常为决定因子。近年来的研究认为胰岛β细胞是一个氧化应激易受损害的器官,与T2DM的β细胞功能进行性减退有关,高糖毒性及脂毒性在T2DM的发生发展过程中均起到重要作用,
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第21期4851-4853,共3页 Chinese Journal of Gerontology
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