期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

DNA甲基化在肿瘤诱发与肿瘤辐射敏感性中的作用

原文传递
导出
摘要 DNA甲基化介导的表观遗传学调控在肿瘤发生、发展和肿瘤治疗中起了重要作用。在大多数恶性肿瘤中，表观遗传学异常主要表现为全基因组低甲基化与局部CpG岛高甲基化，这种DNA甲基化异常可通过影响基因启动子而导致抑癌基因、原癌基因及其他相关基因突变或失活，从而在肿瘤的发生和转化中起重要作用。近年来，表观遗传学方面的干预（如组蛋白去乙酰化和DNA甲基化）被认为可以增强肿瘤细胞的辐射敏感性。
作者 叶爽 谢月霞 袁德晓 邵春林
机构地区 复旦大学放射医学研究所
出处 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2012年第5期548-552,共5页 Chinese Journal of Radiological Medicine and Protection
基金 基金项目：国家自然科学基金（31070758,11179002）
关键词 DNA甲基化异常 辐射敏感性 肿瘤诱发 组蛋白去乙酰化 表观遗传学 遗传学异常 基因启动子 肿瘤发生
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献44

  • 1McCabe MT, Brandes JC, Vertino PM. Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res,2009,15 (12) :3927-3937.
  • 2Cho HJ, Kim SY, Kim KH, et al. The combination effect of sodium butyrate and 5-Aza-2'-deoxyeytidine on radiosensitivity in RKO eolorectal cancer and MCF-7 breast cancer cell lines. World J Surg Oncol,2009,7:49.
  • 3Mirza S, Sharma G, Pandya P, et al. Demethylating agent 5-aza- 2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents. Mol Cell Bioehem, 2010, 342 ( 1-2 ) : 101-109.
  • 4Aypar U, Morgan WF, Banlch JE. Radiation-induced genomic instability: are epigenetic mechanisms the missing link . Int J Badiat Biol,2011,87 (2) :179-191.
  • 5Esteller M. Epigenetie gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet,2007,16 ( 1 ) :R50-59.
  • 6Tan J, Gu Y, Zhang X, et al. Hypermethylation of CpG islands is more prevalent than hypomethylation across the entire genome in breast carcinogenesis. Clin Exp Med,2012. [ Epub ahead of print ].
  • 7Selamat SA, Galler JS, Joshi AD, et al. DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PLoS One, 2011, 6 (6) : e21443.
  • 8Arai E, Kanai Y, Ushijima S, et al. Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues. Int J Cancer, 2006, 119 ( 2 ) : 288-296.
  • 9Cheng X, Blumenthal RM. Mammalian DNA methyhransferases: a structural perspective. Structure ,2008,16 ( 3 ) :341-350.
  • 10Shamsara J, Sharif S, Afsharnezhad S, et al. Association between MGMT promoter hypermethylation and p53 mutation in glioblastoma. Cancei: Invest,2009,27 (8) :825-829.

二级参考文献25

  • 1Waddington CH. Preliminary notes on the development of the wings in normal and mutant strains of drosophila. Proc Natl Acad Sci U S A,1939,25(7) : 299-307.
  • 2Esteller M. Epigenetics in cancer. N Engl J Med, 2008,358 ( 11 ) : 1148-1159.
  • 3Hermann A, Gowher H, Jeltsch A. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci, 2004,61 (19- 20) : 2571-2587.
  • 4Sulewska A,Niklinska W, Kozlowski M, et al. DNA methylation in states of cell physiology and pathology. Folia Histoehem Cytobiol, 2007,45(3) : 149-158.
  • 5Parry TE. Mutagenic mechanisms in leukemia and cancer: a new concept cytosine lack could be as mutagenic as cytosine deamination. Leuk Res,2006,30(9) : 1079-1053.
  • 6Gaudet F, Hodgson JG, Eden A, et al. Induction of tumors in mice by genomic hypomethylation. Science,2003,300(5618) : 489-492.
  • 7Sidiropoulos M, Pampalakis G, Sotiropulou G, et al. Downregulation of human kallikrein 10 ( KLKIO/NESI ) by CpG island hypermethylation in breast, ovarian and prostate cancers. Tumour Biol,2005,26(6) : 324-336.
  • 8Kalinich JF, Catravas GN, Snyder SL. The effect of gamma radiation on DNA methylation. Radiat Res, 1989,117(2): 185-197.
  • 9Tawa R, Kimura Y, Komura J, et al. Effects of X-ray irradiation on genomic DNA methylation levels in mouse tissues. J Radiat Res (Tokyo), 1998,39(4) : 271-278.
  • 10Pogribny I, Raiche J, Slovack M, et al. Dose-dependence, sex-and tissue-speclficity,and persistence of radiation-induced genomic DNA methylation changes. Biochem Biophys Res Commun,200d,320(4) : 1253-1261.

共引文献1

中华放射医学与防护杂志
2012年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部