摘要
目的:探讨PCOS患者未成熟卵母细胞体外成熟(in vitro maturation,IVM)治疗的有效性和安全性。方法:分析比较PCOS合并不孕症自愿要求行IVM或IVF治疗的患者临床结局。结果:IVF组的平均优质胚胎数明显高于IVM组(P<0.05),两者的临床妊娠率(39.22%vs 40.32%)和着床率(24.37%vs 23.89%)无差异(P>0.05)。IVM组的妊娠丢失率为38.0%,高于IVF患者(21.1%,P<0.05),出生婴儿(单胎)的平均体质量组间无统计学差异(P>0.05)。结论:对于PCOS患者进行IVM治疗可以获得与IVF周期相类似的临床妊娠率和着床率;但是IVM治疗后流产率明显增加。
Objective： To evaluate the efficacy and safety in women with PCOS treated by in vitro maturation （IVM） ofoocytes. Methods： The clinical pregnancy, implantation and pregnancy loss rates were compared between women with PCOS undergoing IVF/ICSI or in vitro oocyte maturation-ICSI procedure. Results： The clinical pregnancy and implantation rates were comparable between the two groups： 39.22% and 24.37% in IVF group, 40.32% and 23.89% in IVM group, although the number of good-quality embryo in IVF group were statistically more than in IVM group. The clinical miscarriage rate in IVM group was 38%, which was statistically significantly different from IVF group （21.1%）. Conclusion： The similar clinical pregnancy rate can be acquired with IVM procedure in women with PCOS. However, there is a higher rate of miscarriage when compared with IVF.
出处
《生殖与避孕》
CAS
CSCD
2012年第11期749-753,共5页
Reproduction and Contraception
