摘要
目的探讨氟砷对暴露人群骨代谢的交互作用。方法 2009年选择贵州省清镇市流长乡198例氟砷联合暴露者作为研究对象,分别检测尿氟、尿砷及骨代谢效应标志尿羟脯氨酸(UHYP)和尿I型胶原交联氨基末端肽(UNTX)、骨强度指数(STI),以尿氟(UF)、尿砷(UAs)分组。结果 UNTX含量(26.82 nmol/mmol Cr)在低氟低砷水平低于氟、砷单独作用水平之和[(8.97+20.91)nmol/mmol Cr],UNTX含量(45.19、54.79 nmol/mmol Cr)在低氟高砷、高氟低砷水平高于氟、砷单独作用水平之和[(20.51+20.91)、(8.97+33.68)nmol/mmol Cr)],且氟、砷对NTX的交互作用差异有统计学意义(P<0.01);氟、砷对UHYP、STI的交互作用差异均无统计学意义(P>0.05)。结论在该暴露水平下,氟、砷对NTX在低氟低砷水平主要表现为拮抗作用,在低氟高砷、高氟低砷水平主要表现为协同作用;氟、砷对UHYP、STI不存在交互作用。
Objective To explore the interacive effect of fluoride and arsenic pollution on bone metabolism in exposed population. Methods Totally 198 people with both fluoride and arsenic exposure were selected from Liuchang town of Qinzhen city, Guizhou province. Urinary fluorine （UF）, urinary arsenic （UAs）, urinary hydroxyproline （ UHYP）, urinary cross-linked N-telopeptides of type I collagen （ UNTX ）, and bone strength index （ STI ） of the people were detected. The people were divided into grOups according the contents of UF and UAs. Results The content of UNTX in low fluoride and arsenic combined exposure group（26. 82 nmol/mmol Cr） was lower than those of low fluor- ide exposure group and low arsenic exposure group（8.97 and 20. 91 nmol/mmol Cr）. The content of UNTX for low fluoride concentration and high arsenic concentration,high fluoride concentration and low arsenic concentration exposure groups（45.19 nmol/mmol Cr and 54. 79 nmol/mmol Cr）was higher than those of the low fluoride exposure group and low arsenic exposure group（20. 51 and 20. 91 nmol/mmol Cr,8.97 and 33.68 nmol/mmol Cr）. The interactive effect of fluoride and arsenic on UNTX was significant（ P 〈 0. 01 ）. The interactive effect of fluoride and arsenic on UHYP and STI was not significant（ P 〉 0. 05）. Conclusion Under the specific exposure level, the interaction of low fluoride con- centration and low arsenic concentration on UNTX was antagonistic, with synergistic under low fluoride concentration and high arsenic concentration, high fluoride concentration and high arsenic concentration. No interactive effect of fluoride and arsenic on HYP was observed.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2012年第11期1480-1482,共3页
Chinese Journal of Public Health
基金
国家自然科学基金(30660163
81072248)
贵州省优秀青年科技人才培养计划专项资金(黔科合人字[2007]12号)
贵州省科学技术基金(黔科通[2006]63号)
贵州省教育厅自然科学科研基金(黔教高发[2005]328号)
关键词
氟
砷
骨代谢
交互作用
fluoride
arsenic
bone metabolism
interaction
