摘要
目的探讨肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）和基质金属蛋白酶9（MMP-9）在妊娠期高血压疾病（HDCP）发病机制中的作用。方法选择妊娠期高血压疾病患者（观察组）50例，采用酶联免疫吸附（ELISA）法检测血清TNF-α、IL-6和MMP-9水平，并以20例正常妊娠孕妇（对照组）作为对照。结果观察组患者血清TNF—α、IL-6水平分别为（29．9±4．6）ng／L、（32．6±5．4）ng／L，均明显高于对照组的（8．3±1．5）ng／L、（9．8±1．8）ng／L（t=4．16、4．38，均P〈0．05）；观察组患者血清MMP-9水平为（31．1±4．9）mg／L，显著低于对照组的（117．9±14．1）mg／L（t=3．89，P〈0．05）。MMP-9与TNF—α、IL-6呈负相关（r=-0．372、-0．328，均P〈0．05）。结论HDCP患者TNF-α和IL-6水平升高，MMP-9表达水平下降，TNF-α、IL石和MMP-9在HDCP的发病机制中可能起着重要作用。
Objective To explore the effect of the serum tumor necrosis factor alpha（TNF-ot） ,interleukin 6 （IL-6） and matrix metalloproteinase 9 （MMP-9） in the pathogenesis of hypertensive disorder complicating pregnancy （HDCP）. Methods The serum levels of TNF-α, IL-6 and MMP-9 in 50 patients with HDCP and 20 normal pregnant women were detected by ELISA. Results The serum levels of TNF-α and IL-6 in HDCP group were higher than the control group（t =4.16,4.38,all P 〈0.05）. The serum level of MMP-9 in HDCP group was lower than the control group （ t = 3.89, P 〈 0.05 ）. Negative correlation was observed between TNF-α, IL-6 and MMP-9 in HDCP group （ r = - 0. 372, - 0.328, all P 〈 0.05 ）. Conclusion The serum levels of TNF-ct and IL-6 increased significantly, while the serum level of MMP-9 decreased. TNF-α, IL-6 and MMP-9 may play important roles in pathogenesis and develop- ment of HDCP.
出处
《中国基层医药》
CAS
2012年第23期3527-3528,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
妊娠期高血压疾病
肿瘤坏死因子Α
白细胞介素6
基质金属蛋白酶9
Hypertensive disorder complicating pregnancy
Tumor necrosis factor alpha
Interleukin 6
Matrix metalloproteinase 9
