摘要
目的:探讨炎症前因子与缺血性脑卒中早期病情进展的关系。方法:检测37例进展性脑梗死、95例非进展性脑梗死患者周围血清中白介素-6(IL-6)、白介素-18(IL-18)、hs-CRP水平。结果:进展性脑梗死组血清IL-6、IL-18、hs-CRP水平明显高于非进展性脑梗死组,其中IL-18进入Logistic回归模型。结论:炎症前因子IL-6、IL-18、hs-CRP的高表达在缺血性脑卒中的发病中具有重要作用,特别是IL-18是进展性脑梗死发生发展的重要因素。积极的采取措施抑制这种炎症反应可能是抑制缺血性脑卒中早期神经功能缺损恶化的重要手段。
Objective：To study the relationship between the exponential factors of inflammation and neurological worsening in early stage of ischemic stroke.Methods：The study observed the serum level of interleukin 6（IL-6）,interleukin 18（IL-18） and high-sensitivity C-Reactive Protein（hs-CRP） in the 37 cases with progressing ischemic stroke and 95 cases with non-progressing ischemic stroke.Results： Compared with that in non-progressing ischemic stroke group,the serum level of IL-6,IL-18 and hs-CRP were increased obviously in the progressing ischemic stroke group.IL-18 was list in the Logistic regression model.Conclusion： The high level of IL-6,IL-18 and hs-CRP play an important role in the pathogenesis of progressing ischemic stroke.Especially,IL-18 may be an important factor in the development of progressing ischemic stroke.To positively inhibit such inflammatory response may be an important means to suppress neurological worsening in early stage of ischemic stroke.
出处
《陕西医学杂志》
CAS
2012年第11期1462-1463,1532,共2页
Shaanxi Medical Journal
