摘要
目的探讨血清促甲状腺受体抗体(TRAb)在自身免疫性甲状腺疾病诊治中的作用。方法使用化学发光法分别检测185例甲状腺疾病患者(分为Graves’病组、桥本氏病组和其他甲状腺疾病组)及50例正常对照组的血清TRAb水平(采用RRA方法)、TRAb阳性率(SSTRAb)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平(采用RIA方法)。结果 Graves’病组和对照组的血清TRAb、SSTRAb、FT3和FT4分别为(85.4±30.9)、(5.4±0.7)U/L,92.2%、0%,(15.4±7.8)、(5.1±1.7)mmol/L,(40±16)、(17±3)mmol/L。血清TRAb水平及阳性率在Graves’病组及桥本氏病组均明显高于正常对照组。Graves’病组TRAb水平与血清FT3、FT4水平无相关性。结论血清TRAb水平的检测在Graves'病和桥本氏病的诊断中有重要价值。
Objective To inyestigate the value of serum TRAb levels in diagnosis of patients with autoimmune thyroid disease.Methods The levels of serum TRAb（by RRA）,FT3 and FT4（by RIA） were measured in 185 patients with thyroid disease as well as in 50 normal people.Results The average levels of serum TRAb,SSTRAb,FT3 and FT4 in autoimmune thyroid disease group and normal people group were（85.4±30.7） and（5.4±0.7）U/L,92.2 % and 0%,（15.4±7.8） and（5.1±1.7）mmol/L,（40±16） and（17±3）mmol/L respectively.The average levels and positive rates of serum TRAb were significantly higher in patients with Graves＇ disease and Hashimoto＇s disease than those in normal group.There was no significant correlations between serum TRAb levels and FT3,FT4 levels in patients with Graves＇ disease.Conclusion Detection of TRAb levels are important for diagnosis of autoimmune thyoid disease,especially to Graves＇ disease.
出处
《临床医学》
CAS
2012年第6期14-15,共2页
Clinical Medicine
