摘要
目的:探讨马来酸桂哌齐特联合甲钴胺治疗糖尿病周围神经病变的临床疗效。方法:将患者随机分为两组,两组均采用药物治疗使血糖达标,同时肌注甲钴胺注射液0.5 mg/d,治疗组加用马来酸桂哌齐特注射液320 mg/d,静脉滴注,疗程均为2周。比较两组疗效及正中神经、腓总神经的感觉传导速度(SNCV)和运动传导速度(MNCV)变化。结果:2周后治疗组和对照组总有效率分别为87.9%和56.7%,治疗组明显高于对照组(P<0.05);治疗组正中神经感觉及运动神经传导速度分别为(43.2±2.8)和(48.3±2.7)m/s,对照组分别为(39.3±2.6)和(44.8±2.2)m/s,治疗组明显优于对照组(P<0.05)。结论:马来酸桂哌齐特联合甲钴胺治疗糖尿病周围神经病变疗效优于单用甲钴胺。
Objective： To investigate the clinical effect of cinepazide maleate combined with mecobalamine on diabetic peripheral neuropathy.Methods： 63 patients with diabetic were randomly divided into two groups.The treatment group（n=33）was treated with cinepazide maleate combined with mecobalamine.The control group（n=30）was treated with mecobalamine.Results ： The total effective rate in treatment group was significantly higher than in control group（P0.05）.After treatment the motor nerve conduction velocity（MNCV） and the sensory nerves conduction velocity（SNCV） were obviously improved（P0.01）.And the treatment group was more better than control group after treated（P0.05）.Conclusion： Cinepazide maleate combined with can improve the curative effect on diabetic peripheral neuropathy.
出处
《天津药学》
2012年第5期26-28,共3页
Tianjin Pharmacy
