摘要
目的:优选叶黄素微囊分散片的成型处方。方法:以外观、混悬性、崩解时间及溶出度为综合评价指标,采用单因素试验确定填充剂及润滑剂种类和用量、崩解剂、润湿剂及溶胀性辅料的种类,通过正交试验优选叶黄素微囊分散片的成型工艺处方。结果:最佳处方为以25%羧甲基淀粉钠(CMS-Na)-交联聚乙烯吡咯烷酮(PVPP)(1∶1.5)为崩解剂,6%羟丙基纤维素(HPC)为溶胀性辅料,70%乙醇溶液为润湿剂,所制备的分散片在80 s内完全崩解,10 min溶出度>90%。结论:优选的处方辅料种类及比例适宜、片面光洁,崩解迅速、溶出度高,具有良好的开发前景。
Objective： To optimize forming prescription of lutein microcapsule dispersible tablet. Method： With appearance, suspension, disintegration time and dissolution as comprehensive evaluation indexes, type and amount of filler and lubricant, type of disintegrating agent, wetting agent and swelling accessories were determined by single factor test, forming technology prescription of lutein mierocapsule dispersible tablet was optimized by orthogonal test. Result： Optimum forming prescription was： with consisted of 25% CMS-Na and PVPP （1： 1） as disintegrating agent, 6% HPC as swelling accessory, and 70% ethanol as wetting agent. These prepared dispersible tablet could disintegrate completely within 80 s, dissolution was more than 90% within ten min. Conclusion ： This optimized formulation was rational and stable with smooth appearance, rapid disintegration, high dissolution and good development prospect.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第22期45-48,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
石河子大学生研究训练计划项目(SRP2012216)
科技人员服务企业行动项目(SQ2009GJG4102765)
关键词
叶黄素微囊
分散片
成型工艺
正交试验
lutein microcapsule
dispersible tablet
forming process
orthogonal test
