摘要
目的分析支气管哮喘患者呼出气冷凝液(EBC)中一氧化氮(NO)、8-异前列腺素(8-isoprostane)浓度与肺功能、ACT变化之间的关系。方法病例对照研究。结果 36例患者参加了本次研究,慢性持续期26例、缓解期10例,健康对照19例。缓解期、慢性持续期及健康对照组之间,8-isoprostane、NO与FEV1/pre、ACT评分有统计学差异(P<0.01)。FEVl/pre与NO、8-isoprostane存在负相关性(r=-0.610,P<0.05;r=-0.545,P<0.05)。ACT与NO、8-isoprostane也呈现负相关(r=-0.533,P<0.05;r=-0.584,P<0.05)。结论 EBC中炎性标志物能反映出气道炎症程度,且与肺功能和ACT评估指标有较好的相关性。
Objective To study the relationship between the level of NO, 8-isoprostane in exhaled breath condensate （EBC） and the serious condition of patients with asthma. Methods The data of 36 patients with asthma 10 normal persons were collected for control study. Results 36 patients with asthma were enrolled in this study, 26 cases were chronic persistent and 10 cases were clinical relieve. There are statistically significant between the 8-isoprostane, NO and FEVi/pre, ACT score in chronic persistent, in remission and normal controls. Concentrations of NO and 8-isoprostane in chronic persistent group were significantly higher than those in remission and control group, while FEV1/pre were significantly lower （NO and 8-isoprostane in EBC had negative correlation with FEV1/pre （r =0. 610, P 〈 0.05 ; r = 0. 545, P 〈 0. 05 ） , the same as ACT （ NO and 8-isoprostane in EBC had negative correlation with FEVI/pre （ r = 0. 533, P 〈 0. 05 ; r = 0. 584, P 〈 0. 05 ）. Conclusion Airway inflammation were persistent in asthma patients. NO and 8-isoprostane levels in EBC were associated with the serious condition of asthma, which indicated inflammation indicators might be useful in monitoring serious condi- tion and guiding treatment for asthma patients.
出处
《临床肺科杂志》
2012年第12期2148-2150,共3页
Journal of Clinical Pulmonary Medicine
基金
上海市松江区卫生局重点专科项目
编号:QW09017
