摘要
目的探讨脑梗死合并代谢综合征(MS)患者脂联素水平及其与代谢紊乱的相关性。方法根据国际糖尿病联盟(IDF)MS诊断标准,将74例急性脑梗死患者分为MS组及非MS组;根据患者脑梗死危险因素多少将MS组进一步分为三危险因素MS组和四危险因素及以上MS组。检测各组血浆脂联素和血清高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯(TG)及总胆固醇(TC)水平,并行多因素直线相关分析。结果 MS组脂联素水平较非MS组明显降低,同时伴有TG明显升高;四危险因素及以上MS组脂联素水平较三危险因素MS组明显降低,同时伴有TG水平升高及HDL水平降低;脂联素水平与TG水平呈负相关(b=-1.089,b’=-0.317,P=0.002)。结论脑梗死合并MS患者脂联素水平低;脂联素与代谢紊乱存在相关性。
Aim To investigate the relationship between adiponectin and metabolic abnormalities in patients with acute cerebral infarction complicated by metabolic syndrome （MS）. Methods 74 hospitalized patients with acute is- chemic stroke were studied. All subjects were divided into MS group and non MS group with the criteria of MS published by international diabetes federation （IDF）. For patient with MS, we divided it into three MS components group and four or five MS components group. The level of plasma adiponectin and serum TC, TG, LDL, HDL were detected by EILSA technology and the relationship between adiponectin and serum TC, TG, LDL, HDL were examined by Multiple linear re- gression analysis. Results The patients with acute cerebral infarction complicated by MS showed lower levels of plas- ma adiponectin and higher levels of serum TG compared with control group （ P 〈 0. 05 ）. In four or five MS components group, the value of plasma adiponectin decreased obviously compared with control group and the levels of Serum TG, TC, LDL and HDL increased or decreased compared with control group （ P 〈 0. 05 ）. The result of Multiple linear regression analysis indicated that the levels of plasma adiponectin was significantly associated with TG inversely （ b = - 1. 089, b＇ = -0. 317, P = 0. 002）. Conclusions The value of plasma adiponectin in patients decreased obviously compared with control group. Plasma adiponectin was significantly associated with TG.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2012年第11期1021-1024,共4页
Chinese Journal of Arteriosclerosis
关键词
脂联素
代谢综合征
急性脑梗死
危险因素
Adiponectin
Metabolic Syndrome
Acute Cerebral Infarction
Risk Factor
