摘要
目的探讨原发性失眠（primary insomnia，PI）患者的程序性记忆是否损害及其特征。方法采用类别产生和运动序列任务对36例PI患者及36名对照进行程序性记忆检测，同时用自由词任务检测其陈述性记忆。结果PI患者的类别产生[7．0（6．0，8．8）与9．0（9．0，11．0），Z=5．537，P〈0．01]、运动序列[8．0±3．3与11．5（8．6，13．8），Z=4．152，P〈0．01]和自由词任务的即刻回忆[3．0（2．3，4．0）与6．0（5．0，7．0），Z=6．479，P〈0．01]、延时回忆[9．0±2．2与11．0（10．0，12．0），Z=4．747，P〈0．01]和延时再认[15．0（13．0，15．0）与15．0（15．0，15．0），Z=4．637，P〈0．01]的正确数均明显少于对照组。按失眠类型分层显示早醒组的运动序列、延时回忆与延时再认正确数均明显低于入睡难和睡眠维持难组。结论PI患者程序性记忆和陈述性记忆均受损，早醒组的记忆损害可能更严重。
Objective To explore changes of procedural memory in patients with primary insomnia （PI） and its characteristics. Methods Thirty-six PI patients and 36 controls were enrolled. The procedural memory was respectively detected with category exemplar generation and motor sequence tasks, and the declarative memory was assessed by free recall task. Results Compared with the controls, PI patients showed few correct numbers in the category exemplar generation （ 7.0 （ 6. 0, 8.8 ） vs 9. 0 （ 9. 0, 11.0 ）, Z= 5.537,P〈0.01） and motor sequence task （8.0±3.3 vs 11.5 （8.6, 13.8）, Z= 4. 152,P〈 0.01） and the phases of immediate recall （3.0 （2. 3, 4. 0） vs 6. 0 （5.0, 7.0）, Z = 6. 479 ,P 〈0. 01 ）, delayed recall （9. 0±2. 2 vs 11.0 （10. 0, 12. 0）, Z = 4. 747,P 〈0. 01 ） and delayed recognition （ 15.0 （ 13.0, 15.0） vs 15.0 （15.0, 15.0）, Z = 4.637,P 〈0.01） of the free recall task. Furthermore, the early morning awakening group had significantly lower correct numbers in the motor sequence task, the delayed recall and recognition phases of the free recall task than the difficulty initiating and maintaining sleep groups. Conclusion The procedural and declarative memories are impaired in the PI patients, especially the early momin~ awakening insomniacs.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2012年第11期779-782,共4页
Chinese Journal of Neurology
关键词
入睡和睡眠障碍
记忆
记忆障碍
Sleep initiation and maintenance disorders
Memory
Memory disorders
