摘要
目的:探讨降尿酸治疗对伴发无症状高尿酸血症的高血压患者的血压影响。方法:将140例伴发无症状高尿酸血症的高血压患者随机分为降尿酸组(70例)和对照组(70例),降尿酸组在降压治疗基础上联合降尿酸治疗,对照组常规降压治疗。随访8周,观察治疗前后血尿酸水平,并进行24 h动态血压监测,测血压平均值[24 h平均收缩压(24 h SBP)及舒张压(24 h DBP),白昼平均收缩压(dSBP)及舒张压(dDBP),夜间平均收缩压(nSBP)及舒张压(nDBP)]和血压变异性[24 h SBP、24 h DBP、dSBP、dDBP、nSBP及nDBP的标准差(24 hSBPSD、24 h DBPSD、dSBPSD、dDBPSD、nSBPSD、nDBPSD)]。结果:①与治疗前比较,治疗后降尿酸组血尿酸水平下降更明显(P<0.05),对照组无明显差异(P>0.05);治疗后2组平均血压(24 h SBP、24 h DBP、dSBP、dDBP、nSBP、nDBP)及血压变异性指标(24 h SBPSD、24 h DBPSD、dSBPSD、dDBPSD、nSBPSD、nDBPSD)均下降明显(均P<0.05)。②与对照组治疗后比较,降尿酸组治疗后血尿酸水平下降更明显[(350.5±42.3)μmol/L:(478.6±37.1)μmol/L,P<0.05];血压变异性指标中24 h SBPSD[(10.8±1.5):(13.2±1.6)]、dSBPSD[(7.9±1.3):(10.9±1.3)]、nSBPSD[(6.7±1.2):(9.2±1.7)]下降更明显(均P<0.05)。结论:对伴发无症状高尿酸血症的高血压患者,在常规降压治疗的基础上联合降尿酸治疗能进一步改善血压变异性,可能对患者的预后存在有益的影响。
Objective：To investigate the effect of decreasing trioxypurine therapy on blood pressure and blood pressure variability（BPV） in patients with hypertension and asymptomatic hyperuricemia.Method ： One hundred and forty patients with hypertension and asymptomatic hyperuricemia were randomly divided into test group（n = 70） and control group（n = 70）.Patients in test group underwent routine antihypertensive treatment in addition to decreasing trioxypurine therapy,while patients in control group underwent antihypertensive treatment only.At the end of eight weeks,serum uric acid levels were compared before and after treatment,and 24 h ambulatory blood pressure monitoring was adopted for average blood pressure and BPV.Result： ①Compared with before treatment,serum uric acid levels were significantly decreased in test group（P 0.05）,and there was no difference in control group（P 0.05）.The average blood pressure（24 h SBP,24 h DBP,dSBP,dDBP,nSBP,nDBP） and the BPV（24 h SBPSD,24 h DBPSD,dSBPSD,dDBPSD,nSBPSD,nDBPSD） were significantly decreased in both groups（all P 0.05）.②Compared with control group after treatment,the serum uric acid levels of test group were significantly decreased [（350.5 ± 42.3） μmol / L vs（478.6 ± 37.1） μmol / L,P 0.05].And the parameters of 24 h SBPSD,dSBPSD,nSBPSD in test group were significantly decreased [（10.8 ± 1.5） vs（13.2 ± 1.6）,（7.9 ± 1.3） vs（10.9 ± 1.3）,（6.7 ± 1.2） vs（9.2 ± 1.7）,all P 0.05].Conclusion： Routine anti-hypertension therapy integrated with decreasing trioxypurine therapy can improve BPV in patients with hypertension and asymptomatic hyperuricemia,which may produce a beneficial effect on the prognosis of patients with hypertension and asymptomatic hyperuricemia.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2012年第11期857-860,共4页
Journal of Clinical Cardiology
关键词
高血压
高尿酸血症
动态血压
血压变异性
降尿酸治疗
hypertension
hyperuricemia
ambulatory blood pressure
blood pressure variability
decreasing trioxypurine therapy
