摘要
目的探讨TCT、SCC-Ag单一及联合检测在宫颈病变筛查中的应用价值。方法 189例TCT检测提示异常的妇女,进一步行血清SCC-Ag检测和阴道镜下病理学活检,以病理诊断结果为金标准,计算TCT、SCC-Ag及两者联合检测筛查宫颈病变的灵敏度、特异度、阳性预测值、阴性预测值,评价两者诊断价值。结果 SCC-Ag筛查宫颈病变的灵敏度低于TCT检测(60.32%vs 79.36%),特异度高于TCT检测(92.86%vs 70.63%),两者差异有统计学意义(P<0.05);两者联合检测诊断的特异度为96.31%、阳性预测值为90.00%、诊断符合率为83.69%,与单一TCT检测指标相比,差异有统计学意义(P<0.05)。结论 TCT、SCC-Ag联合检测可降低筛查的假阳性率,提高特异度及诊断符合率,在宫颈病变的筛查中具有一定的应用价值。
Objective To evaluate the application of thinprep cytology test （TCT） and the serum squamous cell carcinoms antigen （SCC-Ag） measurement in the cervical lesion screening. Methods TCT and serum SCC-Ag measurement were performed in 189 patients with cervical lesions. Based on the pathology diagnosis, specificity and sensitivity of these two screening methods were calculated. Results SCC-Ag had lower sensitivity and higher specificity than those of TCT （60.32% vs 79.36% and 92. 86% vs 70. 63%, P 〈 0.05 ）. Co-test of these two methods increased the specificity to 96.31%, but decreased the sensitivity to 57. 14% with positive predictive value of 90.00% and consistency rate to 83.69%. There was significant difference between co-test and single TCT （ P 〈 0.05 ） . Conclusion In the cervical lesion screening, co-test of TCT and SCC-Ag decreased the false positive rate, increased the specificity and diagnosis coincidence rate.
出处
《同济大学学报（医学版）》
CAS
2012年第5期101-104,共4页
Journal of Tongji University(Medical Science)
关键词
TCT检测
SCC—Ag
宫颈病变
筛查
thinprep cytology test
squamous cell carcinom antigen
cervical lesion
screening
