摘要
目的:探讨E-钙粘蛋白(E-cadherin)在宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈鳞癌中的表达及意义。方法:应用免疫组织化学S-P法检测15例正常宫颈上皮组织、56例宫颈CIN组织及19例宫颈鳞癌组织中E-cadherin的表达并应用阳性细胞百分率表示E-cadherin表达的强度。结果:E-cadherin在正常宫颈上皮组织、宫颈CIN组织及宫颈鳞癌组中表达的阳性率分别为100.0%、57.1%及36.8%(P<0.05);在正常宫颈上皮E-cadherin呈现膜表达,而在宫颈CIN及宫颈鳞癌中E-cadherin的膜表达减弱或缺失,呈现出胞浆表达。E-cadherin在宫颈CINⅠ、Ⅱ、Ⅲ中表达的阳性率分别为87.5%、55.0%、35.0%(P<0.05)。在Ⅰ期、Ⅱ期、Ⅲ期宫颈鳞癌组织中E-cadherin表达的阳性率分别为28.6%、40.0%、50.0%,(P>0.05)。结论:宫颈CIN及宫颈鳞癌组织中E-cadherin表达的下调及表达的重新分布参与了CIN及宫颈鳞癌的发生。
Objective To study the expression of E-cadherin in cervical intraepithelial neoplasia（CIN） and cervical squamous cell cancer. Methods 90 paraffin-embedded tissues were chosen,including normal cervical epithelium （n = 15）, CIN （n = 56） and cervical squamous cell cancer （n = 19）.The expression of E-cadherin were detected by the immunohistochemical staining （S-P method）. Results E-cadherin mainly expressed in cell membranes in normal cervical tissue. However, in CIN and cervical squamous cell cancer tissue,the expression of E-cadherin weakened or lost in the cell membrane. Some could be found in cell plasma. The positive expression of E-eadherin in normal cervix, CIN, cervical squamous cell cancer tissue were 100.0% , 57.1% and 36.8% respectively （P 〈 0.05）. The positive expression of E-cadherin in CIN Ⅰ, CIN Ⅱ, CIN Ⅲ were 87.5%, 55.0%, 35.0% respectively （P 〈 0.05）. The positive expression of E-eadherin in cervical squamous cell cancer stage Ⅰ , stage Ⅱ, stage Ⅲ were 28.6%, 40.0%, 50.0% respectively （P 〈 0.05）. Conclusion The downregulation and redistribution of E-cadherin mybe result in the occurrence of CIN and cervical squamous carcinoma.
出处
《实用医学杂志》
CAS
北大核心
2012年第22期3753-3755,共3页
The Journal of Practical Medicine
关键词
宫颈鳞状细胞癌
颈上皮内瘤变
E-钙黏蛋白
Cervical squamons cell cancer
Cervical intraepithelial neoplasia
E-cadherin
