摘要
目的探讨氟康唑不同的给药途径对疗效的影响。方法选取100例患者,随机分成两组,各50例,第一组50例患者分别给予口服氟康唑胶囊150 mg,单次给药;第二组50例患者分别给予氟康唑注射液150 mg,也是单次给药,在45~60 min内滴注完,观察患者用药后1周、下次月经干净后1周的临床症状和体征,血常规、尿常规、肝肾功能,留取标本并送真菌涂片及真菌培养,评估临床疗效。结果第一组用药后1周复查,痊愈的有42例,好转的有4例,无效的有4例,总有效率达92.00%,在下次月经干净后1周复查痊愈的有26例,好转的有5例,无效的有19例,总有效率为62.00%;第二组用药后1周复查发现,痊愈的有41例,好转的有4例,无效的有5例,总有效率达90.00%;在下次月经干净后1周复查痊愈的有27例,好转的有5例,无效的有18例,总有效率为64.00%。两组间总有效率的比较差异无统计学意义（P〉0.05）。有10例患者出现头晕、胃肠不适等不良反应（第一组有4例,第二组有6例）,但是都能够耐受,停药后症状均消失。结论对于长期复发的患者,氟康唑口服与静脉滴注的临床疗效没有明显区别,同时临床发现氟康唑的使用是安全可靠的。
Objective To investigate the effect of different route of administration of Fluconazole on treatment efficacy.Methods 100 patients were randomly assigned to two groups of 50 cases in each group.50 patients in the first group were given oral administration of single dose of 150 mg Fluconazole capsules,and 50 patients in the second group were treated with injection of single dose of 150 mg Fluconazole within 45-60 minutes.Clinical symptoms and signs,blood,urine,liver and kidney function of the patients one week after medication and one week after the end of next menstruation of the patients were observed.And the specimens were taken and sent for fungal smear and fungal culture to assess clinical efficacy.Results In the oral administration group,one week after treatment,there were 42 cases of recovery,and 4 cases of improvement and 4 cases of invalid treatment,with a total effective rate of 92.00%;and one week after the end of next menstruation,there were 26 cases of recovery,5 cases of improvement and 19 cases of invalid treatment,with a total effective rate of 62.00%;in the infusion group,one week after treatment,there were 41 cases of recovery,4 cases of improvement and 5 cases of invalid treatment,with a total effective rate of 90.00%;one week after the end of next menstruation,there were 27 cases of recovery,5 cases of improvement and 18 cases of invalid treatment,with a total effective rate of 64.00%.The total effective rates were not significantly different between the two groups（P 〈0.05）.There were a total of 10 cases of patients with dizziness,gastrointestinal discomfort and other adverse reactions（4 cases in the first group and 6 cases in the second group）,but the symptoms were tolerable and disappeared after discontinuation.Conclusion For patients with long-term recurrence,the clinical efficacies of Fluconazole oral and intravenous infusion are not significantly different and the clinical use of Fluconazole is safe and reliable.
出处
《中国医药导报》
CAS
2012年第21期152-153,共2页
China Medical Herald
关键词
氟康唑
静脉滴注
口服
念珠菌性阴道炎
Fluconazole
Intravenous infusion
Oral administration
Candida vaginitis
