摘要
目的了解儿童下呼吸道感染标本分离病原菌的构成及耐药情况,为临床经验性用药提供参考依据。方法用全自动细菌鉴定仪VETEK系统对2011年1月1日至2012年1月1日我院住院的儿童下呼吸道感染标本进行菌株鉴定及药敏分析。结果 2011年共送检儿童下呼吸道感染标本4619例,分离病原菌2399株,其中革兰氏阴性杆菌2059株,占85.8%,前三位为克雷伯菌属、大肠埃希氏菌、嗜血杆菌属,其中产ESBL大肠埃希菌检出率为50.52%(241/477),产ESBL克雷伯菌属检出率为43.53%(266/611);检出革兰阳性球菌340株,占14.2%,主要是金黄色葡萄球菌、肺炎链球菌,其中检出耐甲氧西林的金黄色葡萄球菌(MRSA)22株。革兰氏阴性杆菌在所检测的抗菌药物中对氨苄西林的耐药率最高,对亚胺培南的耐药率最低;尚未发现对万古霉素耐药的革兰阳性球菌。结论根据病原菌流行情况及耐药规律制定最佳的经验治疗方案,有利于促进抗菌药物的合理应用。
Objective To acquaint pathogens distribution of lower respiratory tract infection and present conditions of the common pathogens drug-resistance, then provide a basis for clinical drug use. Methods VITEK32 automatic bacterial analytic system was used to identify pathogenic organisms of lower respiratory tract separated from children hospitalized from Jan. 2011 to Jan.2012. Results 2399 colonies were isolated from 4619 specimens, among which 2059 strains were Gram-negative organisms （85.8%）, and the top three were Klebsiella spp. Escherichia coli and Haemophilus spp. 241 strains of Escherichia coli and 266 strains of Klebsiella spp. were ESBL positive. 340 strains were Gram-positive （14.2%）, Staphylococcus aureus and Streptococcus pneumonia were primary pathogens. 22 strains of MRSA were detected. The highest drug resistance for gram-negative bacterium was Ampicllin and the lowest was Imipenem. Vancomycin-resistant Gram-positive organisms have not yet found. Conclusion Paying more attention to the epidemic situation and drug resistance of pathogenic bacteria, is conducive to promote the rational use of antibacterial drugs.
出处
《海南医学》
CAS
2012年第22期107-109,共3页
Hainan Medical Journal
关键词
呼吸道感染
病原菌
耐药性
Respiratory tract infection
Pathogenic bacteria
Drug resistance
