摘要
探讨糖尿病患者红细胞膜流动性及其影响因素。方法：对４３例受试者的红细胞膜流动性、脂质过氧化物终产物丙二醛、血清胆固醇、血清甘油三脂和维生素Ｅ进行测定分析。结果：糖尿病组与健康对照组比较，前者红细胞膜流动性和血清ＶＥ含量显著降低（ｔ＝５．４５３、２．３３９，Ｐ＜ ０．０１）；血浆丙二醛、血清胆固醇、甘油三脂含量升高，两者比较有显著性差异（ ｔ＝ ３．０２６、２．３８２、２．９６５，Ｐ＜０．０５）。结论：糖尿病患者红细胞膜流动性与体内脂质成分改变、抗氧化能力减弱密切相关。因此，注意改善糖尿病患者高血糖、高血脂状态的同时，提高糖尿病患者抗氧化能力，对消除其对红细胞膜的损伤，改善其红细胞流动性，预防微血管并发症有重要意义。
Aim: To study the membranous fluidity of the red cells and the effected elements of tile di- abetes patients. Methods:43 patients were given tests and analysis on membranous fluidity of red cells and the end product (Malonyldial dehyde MDA) of peroxidation. serum cholestrol(CHO), serum triglyceride (TG), and Vitamin E(VE). Results: Results showed that as against the contrast group (healthy subjects) diabetec patients showed a remarkable decrease of red cell membranous fluidity (t = 5. 453, P < 0.01 ), and serum VE content(t = 2. 339, P < 0. 01 ); and an increase of serum MDA. CHO. TG(t = 3. 026, 2. 382, 2. 965, P < 0. 01 ). Conclusion: The decrease of diabetes patients membranous fluidity of red cell has close relations with the lipid peroxidation and the change of lipid composition and anti - peroxidation. Therefore, in the conrse of improving the state of hyperglycemia and hyperlipemia, promoting the anti - peroxidation of diabetes patients is of great significance to remedying red cell trauma, improving the red cell membranous fluidity, and preventing micr - ovascular complications.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
2000年第2期37-39,共3页
Journal of Jinan University(Natural Science & Medicine Edition)
