摘要
天花粉蛋白(trichosanthin,TCS)是一种植物蛋白,具有多种药理学活性。近年来类于TCS抗肿瘤的研究有较多进展,但就其抗肿瘤机制尚未达成共识。一种观点认为,TCS可以诱导肿瘤细胞凋亡;另一种观点认为,TCS可以作为核糖体活性抑制蛋白(ribosome inactivating protein,RIP)不可逆地抑制蛋白质合成,从而发挥抗肿瘤作用。本文就TCS的抗肿瘤机制加以综述。
Trichosanthin （TCS）, a plant protein, has multiple pharmacological properties. In recent years, there is much advance on the research of its anti-tumor activity, however, the agreement on TCS- induced anti-tumor mechanism has not been widely achieved. Some people believe that TCS exerts antitumor activities by inducing apoptosis, others treat TCS as a ribsome inactivating protein （RIP）, which inreversiblly inactivates the production of protein. In this review, we talk about the anti-tumor mechanism of TCS.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2012年第6期663-667,共5页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金青年项目(30801283)
上海市科委青年科技启明星项目(09QA1401000)~~
