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N-甲基-4-羟基-5-苯基-2-吡啶酮的合成 被引量：1

Synthesis of N-methyl-4-hydroxy-5-phenyl-2-pyridone
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摘要 以丙二酸和二氯亚砜为起始原料,经氯代、环合、催化氢化及烷基化反应合成了新化合物——N-甲基-5-苯基-4-羟基-2-吡啶酮,总收率38.7%,其结构经1H NMR,IR和EI-MS表征。 A new compound,N-methyl-4-hydroxy-5-phenyl-2-pyridone,was synthesized from malonic acid and thionyl chloride by a four-step reaction of chlorination,cyclization,catalytic hydrogenation and alkylation.The total yield was 38.7%.The structure was characterized by 1HNM,IR and EI-MS.
作者 李晶 赵圣印
机构地区 东华大学化学化工学院与生物工程学院
出处 《合成化学》 CAS CSCD 北大核心 2012年第6期740-741,744,共3页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(21072029) 上海市自然科学基金资助项目(10ZR1400700)
关键词 丙二酸 苯乙腈 4-羟基-2-吡啶酮 合成 malonic acid phenylacetonitrile 4-hydroxy-2-pyridone synthesis
分类号 O626.3 [理学—有机化学] R914.5 [医药卫生—药物化学]
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共引文献9

同被引文献12

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合成化学
2012年 第6期

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