摘要
目的:探讨联合使用铝碳酸镁和兰索拉唑在治疗胃溃疡中的临床价值。方法:选取86例胃溃疡患者,随机分为观察组和对照组,各43例,给予标准三联疗法治疗。一周后,观察组给以兰索拉唑30mg+铝碳酸镁1000mg,对照组仅给以兰索拉唑30mg,连续治疗四周。结果:观察组的总有效率为90.70%,明显高于对照组的74.42%,且差异有统计学意义(χ2=3.9568,P<0.05);观察组复发率为6.98%,对照组复发率为27.91%,有明显差异性(χ2=6.5408,P<0.05)。结论:铝碳酸镁联合兰索拉唑治疗胃溃疡有较好的治疗效果,能够降低远期复发率,不良反应少,值得临床参考。
Objective： To explore the clinical value of hydrotalcite combined with lansoprazole in treatment of gastric ulcer. Methods： Selected 86 cases of patients with gastric ulcer and divided them into observed group and control group medially. They were given standard triple therapy. One week after this therapy, the observed group added lansoprazole 30 mg and hydrotaleite 1000 mg, while the control group added hydrotaleite 1 000 mg, and the treatment lasted four weeks. Results： The total effective rate of the observed group was 90. 70% , higher than that of the control group, whieh was only 74. 42% （χ2 =3.956 8, P 〈0. 05）. The re- lapse rate of the observed group was apparently lower than that of the control group （χ2 = 6. 540 8, P 〈 0.05 ）. Conclusion ： Hydrotal- cite combined with lansoprazole has a great value in treatment of gastric ulcer, and it can decrease relapse rate of gastric ulcer with less adverse reaction. So it is worthy of clinical application.
出处
《中国药物评价》
2012年第2期129-131,共3页
Chinese Journal of Drug Evaluation
关键词
铝碳酸镁
兰索拉唑
胃溃疡
Hydrotalcite
Lansoprazole
Gastric ulcer
