摘要
目的:探讨君子扶正汤(JD)对化疗药物环磷酰胺(CTX)抗肿瘤的增效减毒作用。方法:建立小鼠前胃癌细胞(MFC)荷瘤鼠模型后,随机分为5组,即阴性对照(生理盐水)组、阳性对照(CTX)组(30 mg·kg-1)、JD(高、中、低剂量组)+CTX组(20,10,5 g·kg-1,CTX 30 mg·kg-1),每组10只,给药10 d,观察抑瘤率及各项免疫功能指标的变化。结果:JD+CTX各组肿瘤生长明显低于阴性对照组(P<0.01),JD高、中剂量+CTX组肿瘤生长低于CTX组(P<0.01,P<0.05)。JD高剂量+CTX组与CTX组相比,脾指数、T淋巴细胞增殖能力和胸腺指数、NK细胞活性降低明显升高(P<0.01,P<0.05)。JD高、中剂量+CTX组与CTX组相比,外周血白细胞和骨髓有核细胞计数明显升高(P<0.01,P<0.05)。结论:JD对化疗药物环磷酰胺抗小鼠MFC胃癌具有增效减毒的作用。
Objective： To observe the effect of Junzi Fuzheng decoction in enhancing anti-tumor efficacy of cyclophosphamide and reducing its toxicity. Method： Fifty MFC bearing mice models were established and then divided randomly into five groups： control group, eyclophosphamide （CTX） group （30 mg -kg-1） , Junzi Fuzheng decoction （high, medium and low dose, 20, 10, 5 g .kg^-1） combined with CTX （30 mg·kg^-1） groups. There were 10 mice in each group. After 10 days of treatment, all mice were killed and the tumor inhibiting rates and the index of immunological function were observed. Result： The tumor inhibition rate was higher in each Junzi Fuzheng decoction ＋ CTX group than that in control group （P 〈 0.01 ）. The tumor inhibition rate of high-dose and medium-dose Junzi Fuzheng decoction ＋ CTX group was higher than that in CTX group （P 〈 0.01, P 〈 0.05 ）. The indexes of spleen and thymus as well as proliferation of T lymphocytes and nature killer cell activity in CTX group were lower than those in the high-dose Junzi Fuzheng decoction ＋ CTX group （P 〈 0.01, P 〈 0.05 ）. The counting of peripheral white blood cells and bone marrow nucleated cells in CTX group was lower than those in the high-dose and the medium-dose Junzi Fuzheng decoction ＋ CTX groups （P〈 0.01, P 〈 0. 05）. Conclusion ： Junzi Fuzheng decoction can enhance the efficacy of chemotherapy and reduce its toxicity in the MFC-burdened mice exposed to CTX.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第23期257-260,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
君子扶正汤
环磷酰胺
增效减毒
肿瘤化疗
抑瘤率
Junzi Fuzheng decoction
cyclophosphamide
enhancing effect and reducing toxicity
tumor chemotherapy
tumor inhibiting rate
